아이오니스 파마슈티컬스(Ionis Pharmaceuticals, Inc.)
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionRYDEX VARIABLE TRUST - Biotechnology Fund Variable Annuity
Latest Disclosed Ownership2,820 shares
Latest Disclosed Value $ 111,418
RYDEX VARIABLE TRUST - Biotechnology Fund Variable Annuity reports 5.94% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On August 27, 2025 - RYDEX VARIABLE TRUST - Biotechnology Fund Variable Annuity filed a NPORT-P form disclosing ownership of 2,820 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $111,418 USD as of June 30, 2025. The entity filed a previous NPORT-P on May 29, 2025 disclosing 2,998 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -5.94% during the quarter. The current value of the position is $211,867 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2025-08-27 2025-06-30 NP Ionis Pharmaceuticals EC US4622221004 2,820 -178 -5.94 111 23.33 1.2383
2025-05-29 2025-03-31 NP Ionis Pharmaceuticals EC US4622221004 2,998 90 3.09 90 -10.89 0.9609
2025-03-03 2024-12-31 NP Ionis Pharmaceuticals EC US4622221004 2,908 -20 -0.68 102 -13.68 1.0192
2024-11-29 2024-09-30 NP Ionis Pharmaceuticals EC US4622221004 2,928 43 1.49 117 -14.60 1.0624
2024-08-29 2024-06-30 NP Ionis Pharmaceuticals EC US4622221004 2,885 -289 -9.11 137 0.00 1.2535
2024-05-30 2024-03-31 NP Ionis Pharmaceuticals EC US4622221004 3,174 188 6.30 138 -9.27 1.1669
2024-02-29 2023-12-31 NP Ionis Pharmaceuticals EC US4622221004 2,986 -705 -19.10 151 -9.58 1.2381
2023-11-29 2023-09-30 NP Ionis Pharmaceuticals EC US4622221004 3,691 -69 -1.84 167 8.44 1.4496
2023-08-28 2023-06-30 NP Ionis Pharmaceuticals EC US4622221004 3,760 -379 -9.16 154 4.76 1.2174
2023-05-30 2023-03-31 NP Ionis Pharmaceuticals EC US4622221004 4,139 -1,105 -21.07 148 -25.76 1.1205
2023-02-28 2022-12-31 NP Ionis Pharmaceuticals EC US4622221004 5,244 1,004 23.68 198 5.88 1.1978
2022-11-29 2022-09-30 NP Ionis Pharmaceuticals EC US4622221004 4,240 -442 -9.44 188 8.09 1.3087
2022-08-29 2022-06-30 NP Ionis Pharmaceuticals EC US4622221004 4,682 -620 -11.69 173 -11.73 1.1891
2022-05-26 2022-03-31 NP Ionis Pharmaceuticals EC US4622221004 5,302 -1,555 -22.68 196 -5.77 1.1605
2022-02-28 2021-12-31 NP Ionis Pharmaceuticals EC US4622221004 6,857 1,090 18.90 209 7.77 0.9220
2021-11-29 2021-09-30 NP Ionis Pharmaceuticals EC US4622221004 5,767 -50 -0.86 193 -16.81 0.8131
2021-08-27 2021-06-30 NP Ionis Pharmaceuticals EC US4622221004 5,817 754 14.89 232 2.20 0.9718
2021-05-27 2021-03-31 NP Ionis Pharmaceuticals EC US4622221004 5,063 -968 -16.05 228 -33.24 1.0243
2021-03-01 2020-12-31 NP Ionis Pharmaceuticals EC US4622221004 6,031 -1,101 -15.44 341 0.59 1.3887
2020-11-25 2020-09-30 NP Ionis Pharmaceuticals EC US4622221004 7,132 447 6.69 338 -14.21 1.4124
2020-08-27 2020-06-30 NP Ionis Pharmaceuticals EC US4622221004 6,685 450 7.22 394 34.01 1.5884
2020-06-01 2020-03-31 NP Ionis Pharmaceuticals EC US4622221004 6,235 -396 -5.97 295 -26.50 1.8044
2020-03-02 2019-12-31 NP Ionis Pharmaceuticals EC US4622221004 6,631 336 5.34 401 6.10 1.8542
2019-11-27 2019-09-30 NP Ionis Pharmaceuticals EC US4622221004 6,295 6,295 377 2.0007
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.