Tango Therapeutics, Inc.
US ˙ NasdaqGM ˙ US87583X1090

SecurityTNGX / Tango Therapeutics, Inc.
InstitutionBarclays Plc
Latest Disclosed Ownership368,187 shares
Latest Disclosed Value $ 3,262,136
Barclays Plc reports 0.69% increase in ownership of TNGX / Tango Therapeutics, Inc.

On February 13, 2026 - Barclays Plc filed a 13F-HR form disclosing ownership of 368,187 shares of Tango Therapeutics, Inc. (US:TNGX) valued at $3,262,137 USD as of December 31, 2025. The entity filed a previous 13F-HR/A on March 31, 2026 disclosing 365,680 shares of Tango Therapeutics, Inc.. This represents a change in shares of 0.69% during the quarter. The current value of the position is $7,444,741 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F TANGO THERAPEUTICS COM 87583X109 368,187 2,507 0.69 3,262 6.22 0.0008
2026-03-31 2025-09-30 13F/A-3 TANGO THERAPEUTICS COM 87583X109 365,680 227,030 163.74 3,072 333.15 0.0007
2026-03-19 2025-09-30 13F/A-2 TANGO THERAPEUTICS COM 87583X109 126,281 -12,369 972 0.0003
2025-11-12 2025-09-30 13F TANGO THERAPEUTICS COM 87583X109 365,680 227,030 3,072 0.0007
2026-02-27 2025-06-30 13F/A-2 TANGO THERAPEUTICS COM 87583X109 138,650 75,618 119.97 710 724.42 0.0002
2025-08-14 2025-06-30 13F/A-1 TANGO THERAPEUTICS COM 87583X109 138,650 75,618 1 0.0002
2025-08-13 2025-06-30 13F TANGO THERAPEUTICS COM 87583X109 138,650 75,618 1 0.0001
2026-03-17 2025-03-31 13F/A-1 TANGO THERAPEUTICS COM 87583X109 63,032 -36,742 -36.83 86 -72.08 0.0000
2025-05-15 2025-03-31 13F TANGO THERAPEUTICS COM 87583X109 63,032 -36,742 0 0.0000
2026-03-19 2024-12-31 13F/A-1 TANGO THERAPEUTICS COM 87583X109 99,774 -26,507 -20.99 308 -68.31 0.0001
2025-02-13 2024-12-31 13F TANGO THERAPEUTICS COM 87583X109 99,774 -26,507 0 0.0001
2026-03-31 2024-09-30 13F/A-2 TANGO THERAPEUTICS COM 87583X109 126,281 55,470 78.34 972 60.13 0.0003
2024-11-19 2024-09-30 13F/A-1 TANGO THERAPEUTICS COM 87583X109 126,281 55,470 1 0.0003
2024-11-15 2024-09-30 13F TANGO THERAPEUTICS COM 87583X109 126,281 55,470 1 0.0001
2026-03-23 2024-06-30 13F/A-1 TANGO THERAPEUTICS COM 87583X109 70,811 -112,675 -61.41 608 -58.31 0.0002
2024-08-14 2024-06-30 13F TANGO THERAPEUTICS COM 87583X109 70,811 -112,675 1 0.0002
2026-03-24 2024-03-31 13F/A-1 TANGO THERAPEUTICS COM 87583X109 183,486 -18,413 -9.12 1,457 -27.13 0.0005
2024-05-15 2024-03-31 13F TANGO THERAPEUTICS COM 87583X109 183,486 -18,413 1 0.0005
2026-03-25 2023-12-31 13F/A-1 TANGO THERAPEUTICS COM 87583X109 201,899 114,017 129.74 1,999 102.02 0.0007
2024-02-15 2023-12-31 13F TANGO THERAPEUTICS COM 87583X109 201,899 114,017 2 0.0007
2026-03-26 2023-09-30 13F/A-1 TANGO THERAPEUTICS COM 87583X109 87,882 31,618 56.20 990 431.72 0.0006
2023-11-07 2023-09-30 13F TANGO THERAPEUTICS COM 87583X109 87,882 31,618 1 0.0006
2026-03-30 2023-06-30 13F/A-2 TANGO THERAPEUTICS COM 87583X109 56,264 -3,265 -5.48 187 -20.85 0.0001
2023-09-20 2023-06-30 13F/A-1 TANGO THERAPEUTICS COM 87583X109 56,264 -3,265 0 0.0001
2023-08-03 2023-06-30 13F TANGO THERAPEUTICS COM 87583X109 56,264 -3,265 0 0.0001
2026-03-30 2023-03-31 13F/A-1 TANGO THERAPEUTICS COM 87583X109 59,529 -22,993 -27.86 235 -60.70 0.0001
2023-05-04 2023-03-31 13F TANGO THERAPEUTICS COM 87583X109 59,529 -22,993 0 0.0001
2026-03-30 2022-12-31 13F/A-1 TANGO THERAPEUTICS COM 87583X109 82,522 -37,193 -31.07 598 38.11 0.0003
2023-02-13 2022-12-31 13F TANGO THERAPEUTICS COM 87583X109 82,522 -37,193 1 0.0003
2022-11-03 2022-09-30 13F TANGO THERAPEUTICS COM 87583X109 119,715 -19,121 -13.77 433 -31.16 0.0005
2022-08-12 2022-06-30 13F TANGO THERAPEUTICS COM 87583X109 138,836 15,927 12.96 629 -32.51 0.0004
2022-05-16 2022-03-31 13F TANGO THERAPEUTICS COM 87583X109 122,909 122,909 932 0.0007
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.