오케스트라 바이오메드 홀딩스, Inc.
US ˙ NasdaqGM ˙ US68572M1062

SecurityOBIO / Orchestra BioMed Holdings, Inc.
InstitutionBarclays Plc
Latest Disclosed Ownership94,517 shares
Latest Disclosed Value $ 392,246
Barclays Plc reports 9,451,600.00% increase in ownership of OBIO / Orchestra BioMed Holdings, Inc.

On February 13, 2026 - Barclays Plc filed a 13F-HR form disclosing ownership of 94,517 shares of Orchestra BioMed Holdings, Inc. (US:OBIO) valued at $392,246 USD as of December 31, 2025. The entity filed a previous 13F-HR/A on March 31, 2026 disclosing 1 shares of Orchestra BioMed Holdings, Inc.. This represents a change in shares of 9,451,600.00% during the quarter. The current value of the position is $377,123 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 94,517 94,516 9,451,600.00 392 140.49 0.0001
2026-03-31 2025-09-30 13F/A-3 ORCHESTRA BIOMED HLDGS COM 68572M106 1 -873 -99.89 0 -100.00 0.0000
2026-03-19 2025-09-30 13F/A-2 ORCHESTRA BIOMED HLDGS COM 68572M106 31,785 30,911 163 0.0000
2025-11-12 2025-09-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 1 -873 0 0.0000
2026-02-27 2025-06-30 13F/A-2 ORCHESTRA BIOMED HLDGS COM 68572M106 874 -24,735 -96.59 2 -98.17 0.0000
2025-08-14 2025-06-30 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 874 -24,735 0 0.0000
2025-08-13 2025-06-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 874 -24,735 0 0.0000
2026-03-17 2025-03-31 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 25,609 -12,177 -32.23 110 -27.81 0.0000
2025-05-15 2025-03-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 25,609 -12,177 0 0.0000
2026-03-19 2024-12-31 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 37,786 6,001 18.88 151 -7.36 0.0000
2025-02-13 2024-12-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 37,786 6,001 0 0.0000
2026-03-31 2024-09-30 13F/A-2 ORCHESTRA BIOMED HLDGS COM 68572M106 31,785 23,448 281.25 163 143.28 0.0000
2024-11-19 2024-09-30 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 31,785 23,448 0 0.0000
2024-11-15 2024-09-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 31,785 23,448 0 0.0000
2026-03-23 2024-06-30 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 8,337 -2,111 -20.20 68 21.82 0.0000
2024-08-14 2024-06-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 8,337 -2,111 0 0.0000
2026-03-24 2024-03-31 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 10,448 -9,693 -48.13 55 -69.95 0.0000
2024-05-15 2024-03-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 10,448 -9,693 0 0.0000
2026-03-25 2023-12-31 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 20,141 16,988 538.79 184 577.78 0.0001
2024-02-15 2023-12-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 20,141 16,988 0 0.0001
2026-03-26 2023-09-30 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 3,153 28 0.90 27 28.57 0.0000
2023-11-07 2023-09-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 3,153 28 0 0.0000
2026-03-30 2023-06-30 13F/A-2 ORCHESTRA BIOMED HLDGS COM 68572M106 3,125 -3,829 -55.06 22 -84.56 0.0000
2023-09-20 2023-06-30 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 3,125 -3,829 0 0.0000
2023-08-03 2023-06-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 3,125 -3,829 0 0.0000
2026-03-30 2023-03-31 13F/A-1 ORCHESTRA BIOMED HLDGS COM 68572M106 6,954 6,954 136 0.0001
2023-05-04 2023-03-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 6,954 6,954 0 0.0001
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.