아이오니스 파마슈티컬스(Ionis Pharmaceuticals, Inc.)
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionMorgan Stanley
Latest Disclosed Ownership1,026,509 shares
Latest Disclosed Value $ 77,080,721
Morgan Stanley reports 0.65% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - Morgan Stanley filed a 13F-HR form disclosing ownership of 1,026,509 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $77,080,561 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on May 27, 2026 disclosing 1,019,906 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 0.65% during the quarter. The current value of the position is $77,121,621 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,026,509 6,603 0.65 77,081 -4.47 0.0046
2026-05-27 2025-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,019,906 -160,410 -13.59 80,685 4.49 0.0005
2026-02-13 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,019,906 -160,410 80,685 0.0048
2026-05-27 2025-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,180,316 -181,893 -13.35 77,216 43.47 0.0047
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,180,316 -181,893 77,216 0.0047
2025-08-15 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,362,209 218,028 19.06 53,821 55.91 0.0035
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,144,181 -185,748 -13.97 34,520 -25.75 0.0025
2025-05-15 2024-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,329,929 19,478 1.49 46,494 -11.43 0.0033
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,329,929 19,478 46,494 0.0033
2025-05-14 2024-09-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 1,310,451 297,646 29.39 52,497 8.75 0.0038
2025-02-14 2024-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,310,451 297,646 52,497 0.0038
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,310,451 297,646 52,497 0.0005
2025-05-14 2024-06-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 1,012,805 -150,793 -12.96 48,270 -4.31 0.0037
2024-10-17 2024-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,012,805 -150,793 48,270 0.0037
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,012,805 -150,793 48,270 0.0037
2024-10-17 2024-03-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 1,163,598 73,335 6.73 50,442 -8.55 0.0040
2024-08-16 2024-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,163,598 73,335 50,442 0.0005
2024-05-15 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,163,598 73,335 50,442 0.0040
2024-08-16 2023-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,090,263 56,859 5.50 55,156 17.67 0.0049
2024-02-13 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,090,263 56,859 55,156 0.0049
2023-11-15 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,033,404 -95,484 -8.46 46,875 1.20 0.0048
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,128,888 125,879 12.55 46,318 29.21 0.0046
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,003,009 66,300 7.08 35,848 1.32 0.0038
2023-02-14 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 936,709 240,171 34.48 35,379 14.83 0.0040
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 696,538 -41,439 -5.62 30,809 12.77 0.0042
2022-10-27 2022-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 737,977 218,500 42.06 27,321 41.99 0.0035
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 737,977 218,500 27,321 0.0035
2022-10-27 2022-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 519,477 54,592 11.74 19,241 36.02 0.0026
2022-05-13 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 519,477 54,592 19,241 0.0026
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 464,885 -33,051 -6.64 14,146 -15.30 0.0017
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 497,936 -29,673 -5.62 16,701 -20.65 0.0022
2021-08-23 2021-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 527,609 -40,058 -7.06 21,046 -17.54 0.0028
2021-08-16 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 527,609 -40,058 21,046 0.0006
2021-05-17 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 567,667 144,532 34.16 25,522 6.68 0.0037
2021-02-16 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 423,135 231,047 120.28 23,923 162.49 0.0037
2020-11-13 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 192,088 -36,398 -15.93 9,114 -32.35 0.0018
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 228,486 25,738 12.69 13,472 40.52 0.0030
2020-05-26 2020-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 202,748 -44,984 -18.16 9,587 -35.94 0.0026
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 202,748 -44,984 9,587 736.4815
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 247,732 25,339 11.39 14,965 12.32 0.0035
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 222,393 -113,477 -33.79 13,324 -38.27 0.0035
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 335,870 -51,132 -13.21 21,586 -31.28 0.0057
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 387,002 -243,006 -38.57 31,412 -7.77 0.0089
2019-02-14 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 630,008 476,560 310.57 34,059 330.31 0.0102
2019-04-23 2018-09-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 153,448 -129,185 -45.71 7,915 -32.79 0.0020
2018-11-20 2018-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 153,448 0 7,915 0.0020
2018-11-14 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 153,448 -129,185 7,915
2019-04-23 2018-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 282,633 112,687 66.31 11,776 57.20 0.0032
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 282,633 112,687 11,776
2019-04-23 2018-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 169,946 -21,988 -11.46 7,491 -22.41 0.0021
2018-05-14 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 169,946 -21,988 7,491
2019-04-23 2017-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 191,934 -10,819 -5.34 9,655 -6.06 0.0026
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 191,934 -10,819 9,655
2017-11-14 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 202,753 -65,669 -24.46 10,278 -24.73 0.0031
2017-08-11 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 268,422 122,430 83.86 13,654 132.65 0.0041
2017-05-22 2017-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 145,992 -40,312 -21.64 5,869 -34.13 0.0018
2017-05-12 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 145,992 5,869
2017-02-22 2016-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 186,304 18,317 10.90 8,910 44.74 0.0029
2017-02-13 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 186,304 8,910
2016-11-10 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 167,987 -336,874 -66.73 6,156 -47.65 0.0021
2016-08-12 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 504,861 394,051 355.61 11,759 162.01 0.0042
2016-05-12 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 110,810 -67,100 -37.72 4,488 -59.26 0.0017
2016-02-09 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 177,910 24,465 15.94 11,017 77.61 0.0040
2016-02-08 2015-09-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 153,445 -111,940 -42.18 6,203 -59.39 0.0023
2015-11-09 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 153,445 6,203
2015-08-12 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 265,385 -80,434 -23.26 15,274 -30.63 0.0053
2015-05-14 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 345,819 118,175 51.91 22,019 56.67 0.0081
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 227,644 3,954 1.77 14,054 61.80 0.0051
2014-12-16 2014-09-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 223,690 59,209 36.00 8,686 22.22 0.0033
2014-11-14 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 223,690 8,686
2014-05-13 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 164,481 62,551 61.37 7,107 75.05 0.0030
2014-02-13 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 101,930 -43,831 -30.07 4,060 -25.80 0.0017
2013-11-13 2013-09-30 13F ISIS PHARMACEUTICALS CALIF COM 464330109 145,761 -958 -0.65 5,472 38.78 0.0026
2013-08-08 2013-06-30 13F ISIS PHARMACEUTICALS CALIF COM 464330109 146,719 146,719 3,943 0.0020
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.