아이오니스 파마슈티컬스(Ionis Pharmaceuticals, Inc.)
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionFirst Horizon Advisors, Inc.
Latest Disclosed Ownership0 shares
Latest Disclosed Value $ 0
First Horizon Advisors, Inc. closes position in IONS / Ionis Pharmaceuticals, Inc.

On August 6, 2025 - First Horizon Advisors, Inc. filed a 13F-HR form disclosing ownership of 0 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $0 USD as of June 30, 2025. The entity filed a previous 13F-HR on April 28, 2025 disclosing 112 shares of Ionis Pharmaceuticals, Inc.. The current value of the position is $0 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2025-08-06 2025-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 0 -100.00 0
2025-04-28 2025-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 112 0 0.00 3 0.00 0.0000
2025-02-03 2024-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 112 0 0.00 4 -25.00 0.0001
2024-11-08 2024-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 112 112 4 0.0001
2020-05-05 2020-03-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 0 -35 -100.00 0 -100.00
2020-01-07 2019-12-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 35 0 0.00 2 0.00 0.0001
2019-10-23 2019-09-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 35 0 0.00 2 0.00 0.0002
2019-08-05 2019-06-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 35 7 25.00 2 0.00 0.0002
2019-04-26 2019-03-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 28 0 0.00 2 100.00 0.0002
2019-02-11 2018-12-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 28 0 0.00 1 0.00 0.0001
2018-11-08 2018-09-30 13F/A-2 IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 28 -680 -96.05 1 -96.55 0.0001
2018-11-05 2018-09-30 13F/A-1 IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 28 0 1 0.0001
2018-11-05 2018-09-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 28 -680 1 0.0001
2018-08-06 2018-06-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 708 0 0.00 29 -3.33 0.0024
2018-05-02 2018-03-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 708 0 0.00 30 -18.92 0.0029
2018-01-25 2017-12-31 13F IONIS0PHARMACEUTICALS0INC0COM COMMON0STOCK 462222100 708 -218 -23.54 37 -22.92 0.0035
2017-11-09 2017-09-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 926 0 0.00 48 9.09 0.0049
2017-08-14 2017-06-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 926 -162 -14.89 44 -13.73 0.0048
2017-05-02 2017-03-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 1,088 -98 -8.26 51 59.38 0.0058
2017-02-13 2016-12-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 1,186 0 0.00 32 0.00 0.0041
2016-10-28 2016-09-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 1,186 -261 -18.04 32 -3.03 0.0041
2016-07-29 2016-06-30 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 1,447 115 8.63 33 -26.67 0.0045
2016-05-09 2016-03-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 1,332 541 68.39 45 -6.25 0.0050
2016-02-08 2015-12-31 13F IONIS PHARMACEUTICALS INC COM COMMON STOCK 462222100 791 -123 -13.46 48 33.33 0.0085
2015-11-06 2015-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 914 8 0.88 36 -30.77 0.0056
2015-08-03 2015-06-30 13F/A-1 ISIS PHARMACEUTICALS COMMON STOCK 464330109 906 85 10.35 52 -1.89 0.0075
2015-07-31 2015-06-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 19 52
2015-05-04 2015-03-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 821 821 0.00 53 0.0077
2015-02-05 2014-12-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 0 -734 -100.00 0 -100.00
2014-11-13 2014-09-30 13F/A-1 ISIS PHARMACEUTICALS COMMON STOCK 464330109 734 47 6.84 28 33.33 0.0044
2014-11-13 2014-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 734 47 28 0.0029
2014-08-07 2014-06-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 687 114 19.90 21 -4.55 0.0030
2014-05-02 2014-03-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 573 0 0.00 22 -15.38 0.0031
2014-02-07 2013-12-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 573 512 839.34 26 1,200.00 0.0039
2013-11-15 2013-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 61 61 2 0.0003
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.