촉매 제약, Inc.
US ˙ NasdaqCM ˙ US14888U1016

SecurityCPRX / Catalyst Pharmaceuticals, Inc.
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership2,347,477 shares
Latest Disclosed Value $ 58,123,531
Renaissance Technologies Llc reports 11.42% decrease in ownership of CPRX / Catalyst Pharmaceuticals, Inc.

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 2,347,477 shares of Catalyst Pharmaceuticals, Inc. (US:CPRX) valued at $58,123,531 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 2,650,077 shares of Catalyst Pharmaceuticals, Inc.. This represents a change in shares of -11.42% during the quarter. The current value of the position is $73,405,606 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 2,347,477 -302,600 -11.42 58,124 -6.03 0.0909
2026-02-12 2025-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 2,650,077 -894,753 -25.24 61,853 -11.43 0.0960
2025-11-13 2025-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 3,544,830 293,314 9.02 69,833 -1.03 0.0922
2025-08-13 2025-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 3,251,516 295,200 9.99 70,558 -1.58 0.0939
2025-05-14 2025-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 2,956,316 250,200 9.25 71,691 26.94 0.1085
2025-02-13 2024-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 2,706,116 180,100 7.13 56,477 12.46 0.0836
2024-11-13 2024-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 2,526,016 350,289 16.10 50,217 49.00 0.0755
2024-08-09 2024-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 2,175,727 287,300 15.21 33,702 112,240.00 0.0572
2024-05-13 2024-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 1,888,427 291,000 18.22 30 15.38 0.0473
2024-02-13 2023-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 1,597,427 308,327 23.92 27 73.33 0.0416
2023-11-14 2023-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 1,289,100 134,200 11.62 15 0.00 0.0257
2023-08-11 2023-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 1,154,900 64,800 5.94 16 -16.67 0.0224
2023-05-12 2023-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 1,090,100 -141,412 -11.48 18 -18.18 0.0240
2023-02-13 2022-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 1,231,512 -995,000 -44.69 23 -99.92 0.0313
2022-11-14 2022-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 2,226,512 1,194,900 115.83 28,566 294.99 0.0404
2022-08-12 2022-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 1,031,612 678,500 192.15 7,232 147.08 0.0086
2022-05-13 2022-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 353,112 -69,774 -16.50 2,927 2.24 0.0034
2022-02-11 2021-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 422,886 370,648 709.54 2,863 933.57 0.0036
2021-11-12 2021-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 52,238 52,238 277 0.0004
2020-08-13 2020-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 0 -739,226 -100.00 0 -100.00
2020-05-14 2020-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 739,226 563,526 320.73 2,846 331.87 0.0028
2020-02-13 2019-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 175,700 175,700 -76.23 659 -76.84 0.0005
2019-02-12 2018-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 0 -152,722 -100.00 0 -100.00
2018-11-13 2018-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 152,722 6,256 4.27 577 26.26 0.0006
2018-08-13 2018-06-30 13F/A-1 CATALYST PHARMACEUTICALS COM 14888U101 146,466 -1,243,034 -89.46 457 -86.24 0.0005
2018-08-13 2018-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 1,389,500 3,321
2018-05-14 2018-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 1,389,500 275,400 24.72 3,321 -23.76 0.0036
2018-02-13 2017-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 1,114,100 532,500 91.56 4,356 197.14 0.0048
2017-11-13 2017-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 581,600 -310,200 -34.78 1,466 -40.43 0.0017
2017-08-11 2017-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 891,800 509,400 133.21 2,461 229.89 0.0031
2017-05-12 2017-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 382,400 382,400 -57.12 746 -69.69 0.0010
2017-02-13 2016-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 0 -15,000 -100.00 0 -100.00
2016-11-14 2016-09-30 13F CATALYST PHARMACEUTICALS COM 14888U101 15,000 15,000 0.00 16 0.0000
2016-08-12 2016-06-30 13F CATALYST PHARMACEUTICALS COM 14888U101 0 -175,800 -100.00 0 -100.00
2016-05-13 2016-03-31 13F CATALYST PHARMACEUTICALS COM 14888U101 175,800 175,800 0.00 206 0.0004
2016-02-11 2015-12-31 13F CATALYST PHARMACEUTICALS COM 14888U101 0 0 0 0.0000
2015-08-14 2015-06-30 13F CATALYST PHARM PARTNERS COM 14888U101 0 -21,227 -100.00 0 -100.00
2015-05-13 2015-03-31 13F CATALYST PHARM PARTNERS COM 14888U101 21,227 21,227 0.00 92 0.0002
2015-02-13 2014-12-31 13F CATALYST PHARM PARTNERS COM 14888U101 0 -196,500 -100.00 0 -100.00
2014-11-12 2014-09-30 13F CATALYST PHARM PARTNERS COM 14888U101 196,500 196,500 41.88 652 54.50 0.0018
2014-02-14 2013-12-31 13F CATALYST PHARM PARTNERS COM 14888U101 0 -138,500 -100.00 0 -100.00
2013-11-13 2013-09-30 13F CATALYST PHARM PARTNERS COM 14888U101 138,500 138,500 422 0.0010
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.