아이오니스 파마슈티컬스(Ionis Pharmaceuticals, Inc.)
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionUs Bancorp \de\
Latest Disclosed Ownership5,047 shares
Latest Disclosed Value $ 378,978
Us Bancorp \de\ reports 1.83% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 14, 2026 - Us Bancorp \de\ filed a 13F-HR form disclosing ownership of 5,047 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $378,978 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 30, 2026 disclosing 5,141 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -1.83% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 5,047 -94 -1.83 379 -6.90 0.0001
2026-01-30 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 5,141 437 9.29 407 32.25 0.0005
2025-11-12 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 4,704 419 9.78 308 81.66 0.0004
2025-07-24 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 4,285 1,128 35.73 169 77.89 0.0002
2025-05-08 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 3,157 -1,063 -25.19 95 -35.37 0.0001
2025-02-05 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 4,220 -1,510 -26.35 148 -35.81 0.0002
2024-10-28 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 5,730 -5,320 -48.14 230 -56.46 0.0003
2024-08-07 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,050 -877 -7.35 527 1.74 0.0007
2024-05-08 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,927 -8 -0.07 517 -14.26 0.0007
2024-02-09 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,935 -1,423 -10.65 604 -0.33 0.0009
2023-11-03 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 13,358 -662 -4.72 606 5.22 0.0010
2023-08-10 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 14,020 -2,102 -13.04 575 -0.17 0.0009
2023-05-09 2023-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 16,122 1,302 8.79 576 3.04 0.0010
2023-02-13 2022-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 14,820 -1,378 -8.51 560 -22.04 0.0010
2022-10-27 2022-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 16,198 -1,125 -6.49 717 11.86 0.0015
2022-08-01 2022-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 17,323 -4,135 -19.27 641 -19.37 0.0012
2022-05-11 2022-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 21,458 2,343 12.26 795 36.60 0.0013
2022-02-11 2021-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 19,115 2,732 16.68 582 5.82 0.0009
2021-11-10 2021-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 16,383 2,375 16.95 550 -1.43 0.0010
2021-08-05 2021-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 14,008 422 3.11 558 -8.52 0.0010
2021-04-28 2021-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 13,586 11,068 439.56 610 329.58 0.0012
2021-02-04 2020-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 2,518 903 55.91 142 86.84 0.0003
2020-11-10 2020-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 1,615 253 18.58 76 -5.00 0.0002
2020-08-07 2020-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 1,362 -917 -40.24 80 -25.23 0.0002
2020-05-13 2020-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 2,279 294 14.81 107 -10.83 0.0003
2020-02-04 2019-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 1,985 -428 -17.74 120 -17.24 0.0003
2019-11-08 2019-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 2,413 415 20.77 145 12.40 0.0004
2019-08-13 2019-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 1,998 -26 -1.28 129 -21.34 0.0004
2019-05-08 2019-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 2,024 345 20.55 164 80.22 0.0005
2019-02-13 2018-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 1,679 -1,936 -53.55 91 -51.08 0.0003
2018-10-31 2018-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 3,615 -1,406 -28.00 186 -11.43 0.0005
2018-08-08 2018-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,021 -794 -13.65 210 -18.29 0.0006
2018-05-08 2018-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,815 355 6.50 257 -6.20 0.0008
2018-02-02 2017-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,460 308 5.98 274 4.98 0.0008
2017-11-13 2017-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,152 0 0.00 261 -0.38 0.0008
2017-07-19 2017-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,152 0 0.00 262 26.57 0.0009
2017-05-03 2017-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,152 -115 -2.18 207 -17.53 0.0007
2017-02-08 2016-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,267 176 3.46 251 34.22 0.0009
2016-11-04 2016-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,091 -861 -14.47 187 34.53 0.0007
2016-08-10 2016-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,952 1,634 37.84 139 -20.57 0.0005
2016-05-13 2016-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 4,318 -280 -6.09 175 -38.60 0.0007
2016-02-10 2015-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 4,598 -195 -4.07 285 46.91 0.0011
2015-11-16 2015-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 4,793 619 14.83 194 -19.17 0.0008
2015-08-10 2015-06-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 4,174 -1,454 -25.84 240 -32.96 0.0009
2015-05-08 2015-03-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 5,628 -677 -10.74 358 -8.21 0.0014
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 6,305 -2,344 -27.10 390 16.07 0.0015
2014-11-14 2014-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 8,649 -3,935 -31.27 336 -22.40 0.0014
2014-08-14 2014-06-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 12,584 -27,631 -68.71 433 -75.09 0.0017
2014-05-14 2014-03-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 40,215 29,890 289.49 1,738 322.87 0.0071
2014-02-13 2013-12-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 10,325 1,810 21.26 411 28.44 0.0017
2013-11-07 2013-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 8,515 5,398 173.18 320 280.95 0.0014
2013-08-09 2013-06-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 3,117 3,117 84 0.0004
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.