아이오니스 파마슈티컬스(Ionis Pharmaceuticals, Inc.)
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionProfund Advisors Llc
Latest Disclosed Ownership26,287 shares
Latest Disclosed Value $ 1,973,891
Profund Advisors Llc reports 1.45% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On April 24, 2026 - Profund Advisors Llc filed a 13F-HR form disclosing ownership of 26,287 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $1,973,891 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 6, 2026 disclosing 26,673 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -1.45% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-24 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 26,287 -386 -1.45 1,974 -6.49 0.0725
2026-02-06 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 26,673 741 2.86 2,110 24.41 0.0641
2025-11-06 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 25,932 -2,927 -10.14 1,696 48.77 0.0551
2025-08-07 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 28,859 -6,028 -17.28 1,140 8.37 0.0410
2025-05-08 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 34,887 -8,672 -19.91 1,053 -30.88 0.0457
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 43,559 5,963 15.86 1,523 1.06 0.0556
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 37,596 7,613 25.39 1,506 5.46 0.0570
2024-08-13 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 29,983 -1,587 -5.03 1,429 4.39 0.0530
2024-05-08 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 31,570 2,497 8.59 1,369 -6.94 0.0533
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 29,073 -6,397 -18.03 1,471 -8.58 0.0632
2023-11-13 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 35,470 -814 -2.24 1,609 8.06 0.0890
2023-08-10 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 36,284 -125 -0.34 1,489 14.37 0.0799
2023-05-12 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 36,409 20,564 129.78 1,301 117.56 0.0804
2023-02-02 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 15,845 368 2.38 598 -12.70 0.0388
2022-11-07 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 15,477 -726 -4.48 685 14.17 0.0493
2022-08-01 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,203 -1,389 -7.90 600 -7.98 0.0381
2022-05-10 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 17,592 -1,825 -9.40 652 10.32 0.0274
2022-02-08 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 19,417 -3,474 -15.18 591 -23.05 0.0193
2021-11-12 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 22,891 -1,167 -4.85 768 -19.92 0.0259
2021-08-12 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 24,058 -739 -2.98 959 -13.99 0.0322
2021-05-14 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 24,797 -3,692 -12.96 1,115 -30.79 0.0429
2021-02-09 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 28,489 2,520 9.70 1,611 30.76 0.0704
2020-11-13 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 25,969 -2,127 -7.57 1,232 -25.65 0.0634
2020-08-03 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 28,096 4,045 16.82 1,657 45.73 0.0922
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 24,051 -8,773 -26.73 1,137 -42.66 0.0854
2020-02-18 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 32,824 3,399 11.55 1,983 12.48 0.0863
2019-11-12 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 29,425 -5,142 -14.88 1,763 -20.66 0.0891
2019-08-13 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 34,567 -3,762 -9.82 2,222 -28.58 0.1053
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 38,329 544 1.44 3,111 52.28 0.1496
2019-02-14 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 37,785 -9,137 -19.47 2,043 -15.58 0.1264
2018-11-13 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 46,922 7,934 20.35 2,420 48.92 0.0918
2018-08-13 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 38,988 -2,369 -5.73 1,625 -10.86 0.0649
2018-05-14 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 41,357 -4,400 -9.62 1,823 -20.81 0.0726
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 45,757 -5,723 -11.12 2,302 -11.80 0.0887
2017-11-13 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 51,480 4,206 8.90 2,610 8.52 0.1086
2017-08-11 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 47,274 -2,156 -4.36 2,405 21.04 0.1090
2017-04-25 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 49,430 -4,101 -7.66 1,987 -22.38 0.0888
2017-02-13 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 53,531 -8,401 -13.56 2,560 12.83 0.1179
2016-11-10 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 61,932 -3,193 -4.90 2,269 49.57 0.1079
2016-08-12 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 65,125 -2,619 -3.87 1,517 -44.72 0.0738
2016-05-06 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 67,744 -16,590 -19.67 2,744 -47.46 0.1422
2016-02-05 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 84,334 -627 -0.74 5,223 52.10 0.2478
2015-11-06 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 84,961 -4,482 -5.01 3,434 -33.28 0.1957
2015-08-11 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 89,443 -3,866 -4.14 5,147 -13.36 0.2131
2015-05-08 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 93,309 93,309 0.00 5,941 0.2311
2015-01-30 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 0 -78,528 -100.00 0 -100.00
2014-11-06 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 78,528 805 1.04 3,049 13.85 0.1428
2014-08-08 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 77,723 -17,870 -18.69 2,678 -35.17 0.1174
2014-05-07 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 95,593 19,855 26.22 4,131 36.92 0.1877
2014-02-04 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 75,738 15,378 25.48 3,017 33.14 0.1352
2013-11-07 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 60,360 3,923 6.95 2,266 49.47 0.1203
2013-07-25 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 56,437 56,437 1,516 0.1071
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.