아이오니스 파마슈티컬스(Ionis Pharmaceuticals, Inc.)
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionFirst Trust Advisors Lp
Latest Disclosed Ownership468,363 shares
Latest Disclosed Value $ 35,169,326
First Trust Advisors Lp reports 10.83% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 13, 2026 - First Trust Advisors Lp filed a 13F-HR form disclosing ownership of 468,363 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $35,169,326 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 525,239 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -10.83% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-13 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 468,363 -56,876 -10.83 35,169 -15.36 0.0251
2026-02-13 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 525,239 450,015 598.23 41,552 744.36 0.0302
2025-11-12 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 75,224 18,705 33.10 4,921 120.38 0.0037
2025-08-13 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 56,519 56,519 2,233 0.0018
2025-02-13 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -402,300 -100.00 0 -100.00
2024-11-13 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 402,300 386,106 2,384.25 16,116 1,990.27 0.0154
2024-08-13 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,194 -159,664 -90.79 772 -89.89 0.0008
2024-05-13 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 175,858 -921,872 -83.98 7,623 -86.27 0.0077
2024-02-13 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,097,730 -37,249 -3.28 55,534 7.87 0.0606
2023-11-13 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,134,979 -188,053 -14.21 51,483 -5.16 0.0610
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,323,032 -315,911 -19.28 54,284 -7.33 0.0617
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,638,943 -141,990 -7.97 58,576 -12.92 0.0676
2023-02-09 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,780,933 -296,327 -14.27 67,264 -26.79 0.0800
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,077,260 481,205 30.15 91,877 55.50 0.1191
2022-08-12 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,596,055 -20,235 -1.25 59,086 -1.30 0.0730
2022-05-13 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,616,290 -63,722 -3.79 59,867 17.10 0.0612
2022-02-08 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,680,012 -537 -0.03 51,123 -9.30 0.0497
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,680,549 158,100 10.38 56,366 -7.19 0.0606
2021-10-12 2021-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,522,449 354,640 30.37 60,730 15.67 0.0657
2021-08-16 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,522,449 354,640 60,730 0.0626
2021-05-14 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,167,809 -219,122 -15.80 52,505 -33.04 0.0636
2021-02-02 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,386,931 -10,782 -0.77 78,417 18.24 0.1039
2020-11-05 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,397,713 82,506 6.27 66,321 -14.47 0.1062
2020-07-22 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,315,207 362,734 38.08 77,545 72.20 0.1344
2020-05-06 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 952,473 -46,605 -4.66 45,033 -25.39 0.1020
2020-02-03 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 999,078 10,162 1.03 60,354 1.87 0.1031
2019-11-04 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 988,916 -699,359 -41.42 59,246 -45.40 0.1115
2019-07-30 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,688,275 -903,564 -34.86 108,505 -48.42 0.2046
2019-06-19 2019-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 2,591,839 370,977 16.70 210,380 75.23 0.4184
2019-05-09 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 2,591,839 370,977 210,380
2019-02-07 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 2,220,862 95,138 4.48 120,060 9.50 0.2847
2018-10-25 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,125,724 1,057,960 99.08 109,645 146.43 0.2042
2018-08-02 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,067,764 39,452 3.84 44,494 -1.84 0.0923
2018-04-23 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,028,312 96,291 10.33 45,328 -3.31 0.1041
2018-02-08 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 932,021 -50,323 -5.12 46,881 -5.87 0.1116
2017-10-24 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 982,344 281,733 40.21 49,805 39.74 0.1281
2017-08-02 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 700,611 29,655 4.42 35,640 32.14 0.0951
2017-05-02 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 670,956 -278,878 -29.36 26,972 -40.63 0.0748
2017-02-06 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 949,834 -45,260 -4.55 45,431 24.61 0.1352
2016-11-01 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 995,094 319,368 47.26 36,460 131.67 0.1088
2016-08-04 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 675,726 -415,966 -38.10 15,738 -64.40 0.0496
2016-05-10 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,091,692 -1,235,790 -53.10 44,214 -69.33 0.1420
2016-05-04 2015-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 2,327,482 74,981 3.33 144,141 58.32 0.3741
2016-02-03 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 2,327,482 144,141
2015-11-05 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 2,252,501 473,212 26.60 91,046 -11.09 0.2637
2015-08-04 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 1,779,289 393,695 28.41 102,398 16.07 0.2658
2015-05-04 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 1,385,594 -173,549 -11.13 88,221 -8.35 0.2591
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 1,559,143 1,559,143 96,261 0.3247
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.