AGPU / Axe Compute Inc. - SEC 보고서, 연례 보고, 기업 사업 설명서

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LEI 549300UQE748N2H9LE74
CIK 1446159
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Axe Compute Inc.
SEC Filings (Chronological Order)
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May 18, 2026 EX-99.1

Axe Compute Inc. Reports First Quarter 2026 Financial Results and Provides Business Update

EXHIBIT 99.1 Axe Compute Inc. Reports First Quarter 2026 Financial Results and Provides Business Update Signed $260 Million Landmark Enterprise Contract - Largest in Company History Compute Services Revenue Commenced and Customer Prepayments Grew Appointed President and CFO to Executive Leadership Team PITTSBURGH, May 15, 2026 (GLOBE NEWSWIRE) - Axe Compute Inc. (NASDAQ: AGPU), a virtual neocloud

May 18, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2026 Axe Compute Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2026 Axe Compute Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Numb

May 15, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2026 Axe Compute Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2026 Axe Compute Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Numb

May 15, 2026 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2026 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Axe Compu

May 15, 2026 424B5

Up to $100,000,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-279123 PROSPECTUS SUPPLEMENT (To Prospectus dated May 21, 2024 and the Prospectus Supplements dated May 21, 2024, April 18, 2025, June 2, 2025, and October 29, 2025) Up to $100,000,000 Common Stock This prospectus supplement (this “Prospectus Supplement”) amends and supplements certain information in the prospectus, dated May 21, 2024, filed

May 12, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2026 Axe Compute Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2026 Axe Compute Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Numb

May 12, 2026 EX-99.1

Axe Compute to Host Q1 2026 Financial Results Conference Call Axe Compute Host Conference Call and Webcast on Monday, May 18, 2026 at 8:30 a.m. Eastern Time To Review First Quarter 2026 Financial Results

EXHIBIT 99.1 Axe Compute to Host Q1 2026 Financial Results Conference Call Axe Compute Host Conference Call and Webcast on Monday, May 18, 2026 at 8:30 a.m. Eastern Time To Review First Quarter 2026 Financial Results PITTSBURGH, May 11, 2026 (GLOBE NEWSWIRE) - Axe Compute (NASDAQ: AGPU), a virtual neocloud AI infrastructure platform delivering dedicated enterprise GPU compute capacity at global sc

April 22, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 22, 2026 Axe Compute Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 22, 2026 Axe Compute Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Nu

April 22, 2026 EX-99.1

Axe Compute Secures $260 million, Three-Year Enterprise Contract for 2,304-GPU NVIDIA B300 Deployment Redefining enterprise AI infrastructure: enterprises no longer adapt to cloud constraints — they specify what they need, and Axe Compute delivers it

EXHIBIT 99.1 Axe Compute Secures $260 million, Three-Year Enterprise Contract for 2,304-GPU NVIDIA B300 Deployment Redefining enterprise AI infrastructure: enterprises no longer adapt to cloud constraints — they specify what they need, and Axe Compute delivers it PITTSBURGH, April 22, 2026 (GLOBE NEWSWIRE) - Axe Compute Inc. (NASDAQ: AGPU), a neocloud AI infrastructure platform delivering dedicate

April 16, 2026 EX-10.2

AXE COMPUTE INC. INDUCEMENT STOCK OPTION AWARD NOTICE

Exhibit 10.2 AXE COMPUTE INC. INDUCEMENT STOCK OPTION AWARD NOTICE Optionee: Jeremy Yaukey-Witter You have been awarded a non-qualified option to purchase shares of Common Stock of Axe Compute Inc., a Delaware corporation (the “Company”), as an inducement material to your acceptance of employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4) (the “Inducement Grant”). The Induc

April 16, 2026 EX-10.1

EMPLOYMENT AGREEMENT

Exhibit 10.1 ***Certain identified information has been excluded from this exhibit because it is both (i) not material and (ii) is the type that the registrant treats as private or confidential. EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”) made and entered into effective as of the 16th day of April, 2026 (the “Effective Date”) by and between Jeremy Yaukey-Witter, an individual, res

April 16, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2026 Axe Compute Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2026 Axe Compute Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Nu

April 1, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2026 Axe Compute Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2026 Axe Compute Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Num

April 1, 2026 EX-10.2

AXE COMPUTE INC. INDUCEMENT STOCK OPTION AWARD NOTICE

EdgarFiling Exhibit 10.2 AXE COMPUTE INC. INDUCEMENT STOCK OPTION AWARD NOTICE Optionee: Kyle Okamoto You have been awarded a non-qualified option to purchase shares of Common Stock of Axe Compute Inc., a Delaware corporation (the “Company”), as an inducement material to your acceptance of employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4) (the “Inducement Grant”). The I

April 1, 2026 EX-10.1

EMPLOYMENT AGREEMENT

EdgarFiling Exhibit 10.1 EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”) made and entered into effective as of the 1st day of April, 2026 (the “Effective Date”) by and between Kyle Okamoto, an individual, residing at 6 China Lane, Setauket, NY 11733 (“Employee”) and Axe Compute Inc. headquartered at 91 43rd St., Suite 110, Pittsburgh, PA 15201, a Delaware corporation (“Company”), coll

April 1, 2026 EX-99.1

Axe Compute Reports $12 Million in Executed Agreements Providing $835 Thousand in Estimated Monthly Income Entering Q2 2026 $12M of Contract Value Across 20+ Enterprise Customers, Providing $835 Thousand in Estimated Monthly Income Starting Q2 2026

EXHIBIT 99.1 Axe Compute Reports $12 Million in Executed Agreements Providing $835 Thousand in Estimated Monthly Income Entering Q2 2026 $12M of Contract Value Across 20+ Enterprise Customers, Providing $835 Thousand in Estimated Monthly Income Starting Q2 2026 PITTSBURGH, April 01, 2026 (GLOBE NEWSWIRE) - Axe Compute Inc. (NASDAQ: AGPU), the newly transformed enterprise GPU infrastructure company

March 31, 2026 EX-21.1

AXE COMPUTE INC. SUBSIDIARIES OF THE REGISTRANT

Exhibit 21.1 AXE COMPUTE INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Corporation Delaware Skyline Medical Inc. Delaware

March 31, 2026 EX-99.1

Axe Compute Inc. Reports Full-Year 2025 Financial Results

EXHIBIT 99.1 Axe Compute Inc. Reports Full-Year 2025 Financial Results Completed Strategic Transformation to AI Compute Infrastructure Raised $343.5 Million in Capital to Fund Digital Asset Treasury Strategy Solidified new leadership composition with world class CEO and board members PITTSBURGH, March 31, 2026 (GLOBE NEWSWIRE) - Axe Compute Inc. (NASDAQ: AGPU), a technology company focused on prov

March 31, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2026 Axe Compute Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2026 Axe Compute Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Nu

March 31, 2026 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36790 Axe Compute Inc. (Exact n

March 9, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2026 Axe Compute Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2026 Axe Compute Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Num

February 9, 2026 EX-10.1

AGREEMENT AND RELEASE

Exhibit 10.1 AGREEMENT AND RELEASE This Agreement and Release (“Agreement”) is made by and between Raymond F. Vennare (“Employee”) and Axe Compute Inc. (formerly known as Predictive Oncology Inc.) (“the Company”), each of whom enter into this Agreement intending to be legally bound. 1. Background. The Company and Employee state the following facts and incorporate them by reference into this Agreem

February 9, 2026 EX-10.3

AXE COMPUTE INC. INDUCEMENT STOCK OPTION AWARD NOTICE

Exhibit 10.3 AXE COMPUTE INC. INDUCEMENT STOCK OPTION AWARD NOTICE Optionee: Christopher Miglino You have been awarded a non-qualified option to purchase shares of Common Stock of Axe Compute Inc., a Delaware corporation (the “Company”), as an inducement material to your acceptance of employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4) (the “Inducement Grant”). The Induce

February 9, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2026 Axe Compute Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2026 Axe Compute Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File

February 9, 2026 EX-99.1

Axe Compute Appoints Christopher Miglino as Chief Executive Officer, Ushering in a New Era of Decentralized Compute

EXHIBIT 99.1 Axe Compute Appoints Christopher Miglino as Chief Executive Officer, Ushering in a New Era of Decentralized Compute PITTSBURGH, Feb. 09, 2026 (GLOBE NEWSWIRE) - Axe Compute (or the “Company”) (Nasdaq: AGPU) today announced the appointment of Christopher Miglino as Chief Executive Officer, marking a pivotal development in the company’s commitment to decentralized compute and digital in

February 9, 2026 EX-10.2

EMPLOYMENT AGREEMENT

Exhibit 10.2 EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”) made and entered into effective as of February 9, 2026 (the “Effective Date”) by and between Christopher Miglino (“Employee”), an individual, residing at 1688 Bahia Vista, Sarasota FL 34239, and Axe Compute Inc., 91 43rd St., Suite 110, Pittsburgh, PA 15201, a Delaware corporation (“Company”), collectively referred to as “th

January 22, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 15, 2026 Axe Compute Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 15, 2026 Axe Compute Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File

December 12, 2025 EX-10.1

AMENDMENT NO. 1 TO EMPLOYMENT AGREEMENT

Exhibit 10.1 AMENDMENT NO. 1 TO EMPLOYMENT AGREEMENT This Amendment No. 1 ("Amendment") to the Employment Agreement dated November 1, 2022 (the “Employment Agreement”) is made and entered into effective as of December 10, 2025, by and between Raymond F. Vennare, an individual ("Employee"), and Predictive Oncology Inc., a Delaware corporation ("Company"). WHEREAS, the Board of Directors of the Comp

December 12, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 10, 2025 Axe Compute Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 10, 2025 Axe Compute Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File

December 12, 2025 EX-FILING FEES

(f/k/a Predictive Oncology Inc.) (Exact Name of Registrant as Specified in its Charter)

Exhibit 107 Calculation of Filing Fee Tables S-8 Axe Compute Inc. (f/k/a Predictive Oncology Inc.) (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee 1 Equity Common Stock, pa

December 12, 2025 EX-99.1

Predictive Oncology Becomes Axe Compute, Expanding Into High-Performance AI Infrastructure

EXHIBIT 99.1 Predictive Oncology Becomes Axe Compute, Expanding Into High-Performance AI Infrastructure NEW YORK, Dec. 12, 2025 (GLOBE NEWSWIRE) - Axe Compute Inc. (NASDAQ: AGPU) (the “Company” or “Axe Compute”) today announced that it has changed its name to Axe Compute Inc., with its common stock to begin trading on Nasdaq under the ticker symbol AGPU on December 12, 2025. Axe Compute will conti

December 12, 2025 S-8

As Filed with the Securities and Exchange Commission on December 12, 2025

As Filed with the Securities and Exchange Commission on December 12, 2025 Registration No.

December 11, 2025 EX-3.2

THIRD Amended and Restated BYLAWS of AXE COMPUTE INC. Effective as of December 11, 2025 ARTICLE 1. OFFICES

Exhibit 3.2 THIRD Amended and Restated BYLAWS of AXE COMPUTE INC. Effective as of December 11, 2025 ARTICLE 1. OFFICES Section 1.01. Registered Office. The registered office of the Corporation shall be in the City of Wilmington, County of New Castle, State of Delaware. Section 1.02. Other Offices. The Corporation may also have offices at such other places both within and without the State of Delaw

December 11, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 9, 2025 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 9, 2025 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

December 11, 2025 EX-3.1

CERTIFICATE OF AMENDMENT TO THE CERTIFICATE OF INCORPORATION OF PREDICTIVE ONCOLOGY INC. (a Delaware corporation)

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE CERTIFICATE OF INCORPORATION OF PREDICTIVE ONCOLOGY INC. (a Delaware corporation) Predictive Oncology Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), hereby certifies as follows: 1. That the Board of Directors of the Corporation (the “Board”) has duly

December 2, 2025 EX-99.1

Predictive Oncology Regains Compliance with Nasdaq's Minimum Stockholders' Equity Requirement

EXHIBIT 99.1 Predictive Oncology Regains Compliance with Nasdaq's Minimum Stockholders' Equity Requirement PITTSBURGH, Dec. 02, 2025 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI), a AI-driven drug discovery company that has expanded its business to include a digital asset strategy focused on ATH, the native utility token of the Aethir network, today announced that on December 1, 2025,

December 2, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2025 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

November 25, 2025 EX-3.1

AMENDMENT NO. 1 TO THE PREDICTIVE ONCOLOGY INC. 2024 EQUITY INVENTIVE PLAN

Exhibit 3.01 AMENDMENT NO. 1 TO THE PREDICTIVE ONCOLOGY INC. 2024 EQUITY INVENTIVE PLAN THIS AMENDMENT NO. 1 (the “Amendment”) to the Predictive Oncology Inc. 2024 Equity Incentive Plan (the “Plan”) is adopted as of October 14, 2025, subject to and effective upon the approval of the shareholders of Predictive Oncology Inc. (the “Company”) at the Company’s 2025 annual meeting of stockholders. W I T

November 25, 2025 424B3

Up to 14,903,393 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-291021 PROSPECTUS Up to 14,903,393 Shares of Common Stock This prospectus relates to the possible resale, from time to time by the selling stockholders named in this prospectus, of up to an aggregate of 14,903,393 shares (the “Shares”) of our common stock, par value $0.01 per share (“common stock”), underlying pre-funded warrants (the “Warrants

November 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 25, 2025 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 25, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organi

November 24, 2025 424B3

Up to 5,970,181 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-291022 PROSPECTUS Up to 5,970,181 Shares of Common Stock This prospectus relates to the possible resale, from time to time by the selling stockholders named in this prospectus, of up to an aggregate of 2,547,789 shares (the “PIPE Shares”) of our common stock, par value $0.01 per share (“common stock”), consisting of (i) 36,237 shares (the “Augu

November 21, 2025 CORRESP

November 21, 2025

November 21, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, D.C. 20549 Attn: Lauren Nguyen, Office Chief Juan Grana, Staff Attorney Re: Predictive Oncology Inc. Registration Statement on Form S-3 Filed October 22, 2025 File No. 333-291021 Acceleration Request Requested Date: November 25, 2025 Requested Time: 4:00 P.M. Eastern Tim

November 20, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 20, 2025 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 20, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 20, 2025 CORRESP

November 20, 2025

November 20, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, D.C. 20549 Attn: Lauren Nguyen, Office Chief Juan Grana, Staff Attorney Re: Predictive Oncology Inc. Registration Statement on Form S-3 Filed October 22, 2025 File No. 333-291022 Acceleration Request Requested Date: November 21, 2025 Requested Time: 4:00 P.M. Eastern Tim

November 20, 2025 EX-FILING FEES

Security Type

Exhibit 107 Calculation of Filing Fee Tables S-3 Predictive Oncology Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carr

November 20, 2025 S-3/A

As filed with the Securities and Exchange Commission on November 20, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology

Registration No. 333-291022 As filed with the Securities and Exchange Commission on November 20, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of

November 17, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 17, 2025 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 17, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organi

November 17, 2025 EX-99.1

1 This presentation contains “forward - looking statements” as defined by the Private Securities Litigation Reform Act of 1995, Section 27A of the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended. This presentation al

Exhibit 99.1 1 This presentation contains “forward - looking statements” as defined by the Private Securities Litigation Reform Act of 1995, Section 27A of the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended. This presentation also includes express and implied forward - looking statements regarding the Company’s current expectations, estimates, opinions and belief

November 14, 2025 EX-99.1

Predictive Oncology Reports Third Quarter 2025 Financial Results and Provides Update on Digital Asset Strategy Company to host investor conference call and webcast on Monday, November 17th, at 9:00am EST

EXHIBIT 99.1 Predictive Oncology Reports Third Quarter 2025 Financial Results and Provides Update on Digital Asset Strategy Company to host investor conference call and webcast on Monday, November 17th, at 9:00am EST PITTSBURGH, Nov. 14, 2025 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), an AI-driven drug discovery company that has expanded its business to include a digital asset strategy

November 14, 2025 EX-10.2

SECURITIES PURCHASE AGREEMENT

Exhibit 10.2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of August 26, 2025, between Predictive Oncology Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature page hereto (including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the terms and conditions set

November 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predi

November 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2025 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

October 29, 2025 424B5

Up to $18,330,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-279123 PROSPECTUS SUPPLEMENT (To Prospectus dated May 21, 2024 and the Prospectus Supplements dated May 21, 2024, April 18, 2025, and June 2, 2025) Up to $18,330,000 Common Stock This prospectus supplement (this “Prospectus Supplement”) amends and supplements certain information in the prospectus, dated May 21, 2024, filed with the Securitie

October 29, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 29, 2025 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 29, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organiz

October 28, 2025 ARS

FORM ARS

81,7('67$7(6 6(&85,7,(6$1'(;&+$1*(&200,66,21 :DVKLQJWRQ'&  )250.

October 27, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(

October 22, 2025 S-3

As filed with the Securities and Exchange Commission on October 22, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of

Registration No. 333- As filed with the Securities and Exchange Commission on October 22, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of incorporation or organiza

October 22, 2025 EX-FILING FEES

Security Type

Calculation of Filing Fee Tables S-3 Predictive Oncology Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward In

October 22, 2025 S-3

As filed with the Securities and Exchange Commission on October 22, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of

Registration No. 333- As filed with the Securities and Exchange Commission on October 22, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of incorporation or organiza

October 22, 2025 EX-FILING FEES

Security Type

Calculation of Filing Fee Tables S-3 Predictive Oncology Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward In

October 16, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 16, 2025 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 16, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

October 15, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(

October 8, 2025 EX-99.1

Predictive Oncology Inc. Announces Closing of $343.5 Million in Private Placements to Initiate Digital Asset Treasury Strategy Investment creates the world’s first Strategic Compute Reserve Strategy complements Predictive Oncology’s AI/ML-driven drug

EXHIBIT 99.1 Predictive Oncology Inc. Announces Closing of $343.5 Million in Private Placements to Initiate Digital Asset Treasury Strategy Investment creates the world’s first Strategic Compute Reserve Strategy complements Predictive Oncology’s AI/ML-driven drug discovery and development activities PITTSBURGH, Oct. 08, 2025 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (“Predictive Oncology” or the

October 8, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 7, 2025 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 7, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

September 30, 2025 EX-10.6

STRATEGIC ADVISOR AGREEMENT

Exhibit 10.6 STRATEGIC ADVISOR AGREEMENT This Strategic Advisor Agreement (the “Agreement”) is entered into as of October , 2025 (the “Effective Date”), by and between Predictive Oncology, Inc., a Delaware corporation with its principal place of business at 91 43rd Street, Suite 110, Pittsburgh, Pennsylvania 15201 (“Company”), and DNA Holdings Venture, Inc., a Puerto Rico corporation with its prin

September 30, 2025 EX-99.2

AETHIR DIGITAL ASSET TREASURY: POWERING THE AI INFRASTRUCTURE REVOLUTION Infrastructure - Backed Yield via the World’s Largest Decentralized GPU Network and $ATH Token CONFIDENTIAL DNA HOLDINGS VENTURES, INC This presentation is being delivered to a

Exhibit 99.2 AETHIR DIGITAL ASSET TREASURY: POWERING THE AI INFRASTRUCTURE REVOLUTION Infrastructure - Backed Yield via the World’s Largest Decentralized GPU Network and $ATH Token CONFIDENTIAL DNA HOLDINGS VENTURES, INC This presentation is being delivered to a limited number of parties for discussion purposes only and shall not form the basis for or be relied on in connection with any contractua

September 30, 2025 EX-10.2

SECURITIES PURCHASE AGREEMENT

Exhibit 10.2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of September [●], 2025, between Predictive Oncology, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the terms and co

September 30, 2025 EX-10.5

September 29, 2025

Exhibit 10.5 September 29, 2025 PREDICTIVE ONCOLOGY 91 43rd Street, Suite 110 Pittsburgh, Pennsylvania 15201 Re: Predictive Oncology ATH Digital Asset Treasury Transaction Ladies and Gentlemen: Reference is made to the Securities Purchase Agreement, dated as of September 29, 2025 (the “SPA”), by and among Predictive Oncology Inc., a Delaware corporation (the “Company”) and the purchasers set forth

September 30, 2025 EX-4.4

COMMON STOCK PURCHASE WARRANT PREDICTIVE ONCOLOGY, Inc.

Exhibit 4.4 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

September 30, 2025 EX-4.1

FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT PREDICTIVE ONCOLOGY, Inc.

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

September 30, 2025 EX-4.2

FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT PREDICTIVE ONCOLOGY, Inc.

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

September 30, 2025 EX-99.3

Risks Related to the Company’s Business and Aethir Strategy and Holdings

Exhibit 99.3 Risks Related to the Company’s Business and Aethir Strategy and Holdings We intend to use the net proceeds from the Private Placements (as defined in our Current Report on Form 8-K, filed with the U.S. Securities and Exchange Commission on September 29, 2025) principally to purchase digital assets, including Aethir tokens, the price of which has been, and will likely continue to be, h

September 30, 2025 EX-10.3

REGISTRATION RIGHTS AGREEMENT

Exhibit 10.3 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is made and entered into as of September [●], 2025, between Predictive Oncology, Inc., a Delaware corporation (the “Company”), and each of the several purchasers signatory hereto (each such purchaser, a “Purchaser” and, collectively, the “Purchasers”). This Agreement is made pursuant to the Securities

September 30, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 25, 2025 Predictive Onc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 25, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organ

September 30, 2025 EX-3.1

AMENDMENT NO. 2 TO THE SECOND AMENDED AND RESTATED BYLAWS OF PREDICTIVE ONCOLOGY INC.

Exhibit 3.1 AMENDMENT NO. 2 TO THE SECOND AMENDED AND RESTATED BYLAWS OF PREDICTIVE ONCOLOGY INC. The Second Amended and Restated Bylaws, as amended on September 9, 2022 (the “Bylaws”) of Predictive Oncology Inc., a Delaware corporation (the “Company”) are hereby amended pursuant to Section 6.06 of the Bylaws as follows: 1. Section 3.02 of the Bylaws is hereby deleted in its entirety and replaced

September 30, 2025 EX-10.7

ASSET MANAGEMENT AGREEMENT

Exhibit 10.7 ASSET MANAGEMENT AGREEMENT This ASSET MANAGEMENT AGREEMENT (this “Agreement”), effective October [], 2025 (the “Effective Date”), is entered into by and between Predictive Oncology Inc. (the “Client”), and DNA Holdings Venture, Inc. (the “Asset Manager” and, together with the Client, the “Parties”). WHEREAS, the Client wishes to appoint the Asset Manager to manage certain assets of th

September 30, 2025 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of September [●], 2025, between Predictive Oncology, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the terms and co

September 30, 2025 EX-4.3

PLACEMENT AGENT COMMON STOCK PURCHASE WARRANT PREDICTIVE ONCOLOGY, Inc.

Exhibit 4.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

September 30, 2025 EX-10.4

LOCK-UP AGREEMENT

Exhibit 10.4 LOCK-UP AGREEMENT , 2025 Predictive Oncology Inc. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 Re: (i) Securities Purchase Agreement, dated as of , 2025 (the “Cash Purchase Agreement”), between Predictive Oncology Inc. (the “Company”) and the purchasers signatory thereto (each, a “Cash Purchaser” and, collectively, the “Cash Purchasers”), and (ii) Securities Purchase Agreement, date

September 29, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 29, 2025 Predictive Onc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 29, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commis

September 29, 2025 EX-99.1

Predictive Oncology Inc. Announces Private Placements of $344 Million to Initiate a Digital Asset Treasury Strategy Focused on Aethir (ATH) Tokens Shawn Matthews, CEO of DNA Holdings and Former CEO of Cantor Fitzgerald, will join the Board of Directo

EXHIBIT 99.1 Predictive Oncology Inc. Announces Private Placements of $344 Million to Initiate a Digital Asset Treasury Strategy Focused on Aethir (ATH) Tokens Shawn Matthews, CEO of DNA Holdings and Former CEO of Cantor Fitzgerald, will join the Board of Directors upon the closing of the private placements Predictive Oncology continues to execute on its artificial intelligence and machine learnin

September 25, 2025 EX-99.1

Predictive Oncology Announces 1-for-15 Reverse Stock Split Common Stock Will Begin Trading on Split-Adjusted Basis on September 30, 2025

Exhibit 99.1 Predictive Oncology Announces 1-for-15 Reverse Stock Split Common Stock Will Begin Trading on Split-Adjusted Basis on September 30, 2025 PITTSBURGH, PA. – September 25, 2025 – Predictive Oncology Inc. (Nasdaq: POAI), a leader in AI-driven drug development and discovery, today announced that it will effect a 1-for-15 reverse stock split of its issued and outstanding shares of common st

September 25, 2025 EX-3.1

CERTIFICATE OF AMENDMENT TO THE CERTIFICATE OF INCORPORATION OF PREDICTIVE ONCOLOGY INC. (a Delaware corporation)

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE CERTIFICATE OF INCORPORATION OF PREDICTIVE ONCOLOGY INC. (a Delaware corporation) Pursuant to Section 242 of the Delaware General Corporation Law, the undersigned, being the Chief Executive Officer of Predictive Oncology Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), does hereby certify that the fo

September 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 19, 2025 Predictive Onc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 19, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organ

September 12, 2025 EX-10.1

PREDICTIVE ONCOLOGY INC. 2024 EQUITY INCENTIVE PLAN RESTRICTED STOCK UNIT AWARD AGREEMENT

Exhibit 10.1 PREDICTIVE ONCOLOGY INC. 2024 EQUITY INCENTIVE PLAN RESTRICTED STOCK UNIT AWARD AGREEMENT Name of Grantee: [●] No. of Restricted Stock Units: [●] Grant Date: [●] Pursuant to the Predictive Oncology Inc. 2024 Equity Incentive Plan, as amended from time to time (the “Plan”), Predictive Oncology Inc. (the “Company”) hereby grants an award of the number of Restricted Stock Units listed ab

September 12, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 9, 2025 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 9, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organi

September 8, 2025 D

D

X0708 D LIVE 0001446159 Predictive Oncology Inc. 91 43RD STREET SUITE 110 PITTSBURGH PA PENNSYLVANIA 15201 412-432-1500 DELAWARE Precision Therapeutics Inc. Precision Therapeutic Inc. Skyline Medical Inc. Corporation true Raymond F. Bennare 91 43rd Street Suite 110 Pittsburgh PA PENNSYLVANIA 15201 Executive Officer Director Veena Rao 91 43rd Street Suite 110 Pittsburgh PA PENNSYLVANIA 15201 Direct

September 2, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 26, 2025 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 26, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organiza

August 18, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(

August 14, 2025 EX-99.1

Predictive Oncology Reports Second Quarter 2025 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Predictive Oncology Reports Second Quarter 2025 Financial Results and Provides Corporate Update PITTSBURGH, Aug. 14, 2025 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, and CLIA laboratory to accelerate oncologic drug discover

August 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive

August 7, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6

July 29, 2025 424B3

Up to 1,921,706 Shares of Common Stock

Filed pursuant to Rule 424(b)(3) Registration No. 333-288782 PROSPECTUS Up to 1,921,706 Shares of Common Stock This prospectus relates to the resale from time to time by YA II PN, LTD., a Cayman Islands exempt limited company (“Yorkville” or the “Selling Stockholder”) of up to 1,921,706 shares of our Common Stock, par value $0.01 per share (“Common Stock”). The shares of Common Stock to which this

July 24, 2025 LETTER

LETTER

July 24, 2025 Josh Blacher Interim Chief Financial Officer Predictive Oncology Inc.

July 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 23, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 23, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizati

July 24, 2025 CORRESP

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 July 24, 2025 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Margaret Sawicki Re: Predictive Oncology Inc. Acceleration Request for Registration Statement on Form S-1 File No. 333-288782 Requested Date: July 28, 2025 Requested Time

July 18, 2025 EX-99.1

EXPLANATORY NOTE

Exhibit 99.1 EXPLANATORY NOTE Predictive Oncology is revising and recasting certain financial and other information included in its 2024 Form 10-K. The relevant information in the 2024 Form 10-K is being updated to retrospectively reflect the results of the Eagan Business as discontinued operations as a result of meeting the criteria for discontinued operations during the three months ended March

July 18, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) Predictive Oncology Inc.

July 18, 2025 S-1

As Filed with the Securities and Exchange Commission on July 18, 2025

As Filed with the Securities and Exchange Commission on July 18, 2025 Registration No.

July 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizati

July 11, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 8, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizatio

July 8, 2025 EX-10.1

Standby Equity Purchase Agreement, dated as of July 1, 2025, by and between the Registrant and YA II PN, Ltd.

Exhibit 10.1 STANDBY EQUITY PURCHASE AGREEMENT THIS STANDBY EQUITY PURCHASE AGREEMENT (this “Agreement”) dated as of July 1, 2025 is made by and between YA II PN, LTD., a Cayman Islands exempt limited company (the “Investor”), and PREDICTIVE ONCOLOGY INC., a company incorporated under the laws of the State of Delaware (the “Company”). The Investor and the Company may be referred to herein individu

July 8, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 1, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 1, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizatio

June 11, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

June 6, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

June 2, 2025 424B5

Up to $3,398,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-279123 PROSPECTUS SUPPLEMENT To Prospectus Supplement dated April 18, 2025 (To Prospectus and Prospectus Supplement dated May 21, 2024) Up to $3,398,000 Common Stock This prospectus supplement (the “Prospectus Supplement”) amends and supplements certain information in the prospectus supplement, dated April 18, 2025, to the prospectus, dated

May 15, 2025 EX-99.1

Predictive Oncology Reports First Quarter 2025 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Predictive Oncology Reports First Quarter 2025 Financial Results and Provides Corporate Update PITTSBURGH, May 15, 2025 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, and CLIA laboratory to accelerate oncologic drug discovery

May 15, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictiv

April 18, 2025 424B5

Up to $1,491,000 Common Stock

As Filed Pursuant to Rule 424(b)(5) Registration No. 333-279123 PROSPECTUS SUPPLEMENT (To Prospectus and Prospectus Supplement dated May 21, 2024) Up to $1,491,000 Common Stock This prospectus supplement (the “Prospectus Supplement”) amends and supplements certain information in the prospectus, dated May 21, 2024, filed with the Securities and Exchange Commission as part of our registration statem

April 18, 2025 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organiza

April 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organizati

April 1, 2025 EX-99.1

Predictive Oncology Inc. 2024 Equity Incentive Plan

Exhibit 99.1 PREDICTIVE ONCOLOGY INC. 2024 EQUITY INCENTIVE PLAN 1. Purpose. The purpose of the 2024 Equity Incentive Plan (the “Plan”) of Predictive Oncology Inc. (the “Company”) is to increase shareholder value and to advance the interests of the Company by furnishing a variety of economic incentives (“Incentives”) designed to attract, retain and motivate employees, certain key consultants and d

April 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

April 1, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Predictive Oncology Inc.

April 1, 2025 S-8

As Filed with the Securities and Exchange Commission on March 31, 2025

As Filed with the Securities and Exchange Commission on March 31, 2025 Registration No.

April 1, 2025 EX-99.1

Predictive Oncology Reports Year-End 2024 Financial Results and Provides Corporate Update Company continues to progress toward the signing of a definitive merger agreement with Renovaro

EXHIBIT 99.1 Predictive Oncology Reports Year-End 2024 Financial Results and Provides Corporate Update Company continues to progress toward the signing of a definitive merger agreement with Renovaro PITTSBURGH, April 01, 2025 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensiv

March 31, 2025 EX-21.1

List of Subsidiaries. (Filed on March 31, 2025 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference).

Exhibit 21.1 PREDICTIVE ONCOLOGY INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Corporation Delaware Skyline Medical, Inc. Delaware

March 31, 2025 EX-19

Insider Trading Policy

Exhibit 19 PREDICTIVE ONCOLOGY INC. POLICY ON AVOIDANCE OF INSIDER TRADING The Board of Directors of Predictive Oncology Inc., a Delaware corporation (the “Company”), has adopted this Insider Trading Policy for our directors, employees (including officers) and consultants with respect to the trading of the Company’s securities, as well as the securities of publicly traded companies with whom we ha

March 31, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36790 Predictive Oncology Inc.

March 31, 2025 EX-4.7

Exhibit 4.7

Exhibit 4.7 Description of Registrant’s Securities Predictive Oncology Inc. (the “Company”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), namely, our common stock, par value $0.01 per share (“Common Stock”). Description of Common Stock The following description of our Common Stock is a summary and does not purport t

March 20, 2025 EX-99.1

Predictive Oncology Completes Sale of Skyline Medical Assets to DeRoyal Industries Deal positions STREAMWAY® Systems with an established market leader to drive accelerating growth Transaction allows Predictive Oncology to be highly focused on its cor

EXHIBIT 99.1 Predictive Oncology Completes Sale of Skyline Medical Assets to DeRoyal Industries Deal positions STREAMWAY® Systems with an established market leader to drive accelerating growth Transaction allows Predictive Oncology to be highly focused on its core AI-driven drug discovery capabilities and integrate seamlessly with Renovaro Biosciences PITTSBURGH, March 20, 2025 (GLOBE NEWSWIRE) -

March 20, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2025 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 20, 2025 EX-10.1

Asset Purchase Agreement, dated March 14, 2025, by and between Predictive Oncology Inc. and DeRoyal Industries, Inc.

Exhibit 10.1 ASSET PURCHASE AGREEMENT This Asset Purchase Agreement (this “Agreement”) dated as of March 14, 2025 is entered into between Predictive Oncology Inc., a Delaware corporation (“Seller”), and DeRoyal Industries, Inc., a Tennessee corporation (“Buyer”). Capitalized terms used in this Agreement have the meanings given to such terms herein. RECITALS WHEREAS, in addition to its other busine

March 5, 2025 EX-99.1

Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development e

EXHIBIT 99.1 Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development efforts in Europe and the United States Renovaro’s recent strategic acquisition of BioSymetrics vastly expands Predictive Oncology’s bioma

March 5, 2025 EX-10.1

Extension Amendment, dated February 28, 2025, by and between Predictive Oncology Inc. and Renovaro, Inc.

Exhibit 10.1 EXTENSION AGREEMENT This Extension Agreement (“Agreement”) is entered into this 28th day of February 2025, by Predictive Oncology, Inc., a Delaware corporation (the “POI”), and Renovaro, Inc. a Delaware corporation (the, “Renovaro”)(collectively, POI and Renovaro may be referred to as the “Parties”). BACKGROUND WHEREAS, POI and Renovaro entered into a definitive Letter agreement dated

March 5, 2025 EX-10.1

Extension Amendment, dated February 28, 2025, by and between Predictive Oncology Inc. and Renovaro, Inc.

Exhibit 10.1 EXTENSION AGREEMENT This Extension Agreement (“Agreement”) is entered into this 28th day of February 2025, by Predictive Oncology, Inc., a Delaware corporation (the “POI”), and Renovaro, Inc. a Delaware corporation (the, “Renovaro”)(collectively, POI and Renovaro may be referred to as the “Parties”). BACKGROUND WHEREAS, POI and Renovaro entered into a definitive Letter agreement dated

March 5, 2025 EX-99.1

Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development e

EXHIBIT 99.1 Predictive Oncology Moves to Finalize Definitive Merger Agreement With Renovaro Biosciences Predictive receives first tranche of financing to initiate integration of AI/ML platform technologies, core laboratory capabilities and business development efforts in Europe and the United States Renovaro’s recent strategic acquisition of BioSymetrics vastly expands Predictive Oncology’s bioma

March 5, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

March 5, 2025 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2025 Predictive Onco

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation)

February 19, 2025 EX-99.1

Predictive Oncology Announces Registered Direct Offering Priced At-The-Market Under Nasdaq Rules

EXHIBIT 99.1 Predictive Oncology Announces Registered Direct Offering Priced At-The-Market Under Nasdaq Rules PITTSBURGH, Feb. 19, 2025 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), a leader in AI-driven drug discovery and biologics, today announced that it has entered into definitive agreements for the purchase and sale of 363,336 shares of c

February 19, 2025 424B5

PREDICTIVE ONCOLOGY INC. 363,336 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) File No. 333-279123 PREDICTIVE ONCOLOGY INC. 363,336 Shares of Common Stock We are offering 363,336 shares of our common stock, par value $0.01 per share, pursuant to this prospectus supplement and the accompanying prospectus, directly to institutional investors. Our common stock is listed on The Nasdaq Capital Market under the symbol “POAI.”

February 19, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2025 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

February 19, 2025 EX-10.1

Form of Securities Purchase Agreement dated February 18, 2025

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of February 18, 2025, between Predictive Oncology Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condit

February 19, 2025 EX-4.2

Form of Placement Agent Warrant

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

February 19, 2025 EX-99.2

Predictive Oncology Closes Registered Direct Offering

EXHIBIT 99.2 Predictive Oncology Closes Registered Direct Offering PITTSBURGH, Feb. 19, 2025 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), a leader in AI-driven drug discovery and biologics, today closed its previously announced registered direct offering for the purchase and sale of 363,336 shares of common stock at a purchase price of $1.50

January 13, 2025 424B3

1,983,302 Shares of Common Stock Issuable Upon Exercise of Warrants

Filed pursuant to Rule 424(b)(3) Registration No. 333- 281579 PROSPECTUS 1,983,302 Shares of Common Stock Issuable Upon Exercise of Warrants This prospectus relates to the offer and resale from time to time by the selling stockholders named in this prospectus of up to an aggregate of 1,983,302 shares of our common stock, par value $0.01 per share. These shares consist of (i) 958,117 shares of comm

January 6, 2025 EX-1.01

Letter of Intent between Predictive Oncology and Renovaro

Exhibit 1.01 January 1, 2025 Raymond Vennare Predictive Oncology Inc. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 Confidential Dear Raymond, Thank you very much for the opportunity to review Predictive Oncology Inc. (referred to as the “Company”, “Predictive”, or the “Seller”). We have enjoyed our discussions with you to date and are excited about your business model and prospects and very enco

January 6, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 1, 2025 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

January 6, 2025 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 30, 2024 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

January 6, 2025 EX-99.1

Predictive Oncology Announces Agreement to be Acquired by Renovaro - Combination creates immediate scientific synergies by harnessing complementary AI / ML platforms to improve patient outcomes across multiple cancer indications – - Deal terms align

EXHIBIT 99.1 Predictive Oncology Announces Agreement to be Acquired by Renovaro - Combination creates immediate scientific synergies by harnessing complementary AI / ML platforms to improve patient outcomes across multiple cancer indications – - Deal terms align shareholders’ interest, augment business development opportunities and positioning in the capital markets - PITTSBURGH, Jan. 06, 2025 (GL

November 27, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

November 22, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 22, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 13, 2024 EX-99.1

Predictive Oncology Reports Third Quarter 2024 Financial Results and Provides Strategic Update Company initiates process to explore a broad range of strategic alternatives to maximize shareholder value

EXHIBIT 99.1 Predictive Oncology Reports Third Quarter 2024 Financial Results and Provides Strategic Update Company initiates process to explore a broad range of strategic alternatives to maximize shareholder value PITTSBURGH, Nov. 13, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabil

November 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predi

September 20, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 19, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organ

August 21, 2024 CORRESP

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 August 21, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Ms. Jane Park, Staff Attorney Re: Predictive Oncology Inc. Acceleration Request for Registration Statement on Form S-3, as amended File No. 333-281579 Requested Date: A

August 21, 2024 LETTER

LETTER

August 21, 2024 Raymond Vennare Chief Executive Officer Predictive Oncology Inc. 91 43rd Street, Suite 110 Pittsburgh, Pennsylvania 15201 Re: Predictive Oncology Inc. Registration Statement on Form S-3 Filed August 15, 2024 File No. 333-281579 Dear Raymond Vennare: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 reg

August 15, 2024 S-3

As filed with the Securities and Exchange Commission on August 15, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of r

Registration No. 333- As filed with the Securities and Exchange Commission on August 15, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of incorporation or organizat

August 15, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-3 (Form Type) Predictive Oncology Inc.

August 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 14, 2024 EX-99.1

Predictive Oncology Reports Second Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, August 14th, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports Second Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, August 14th, at 8:30am EDT PITTSBURGH, Aug. 14, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository

August 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive

July 29, 2024 EX-4.1

Form of Series A Common Stock Purchase Warrant dated July 26, 2024 (Filed on July 29, 2024 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

EXHIBIT 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

July 29, 2024 EX-4.2

Form of Series B Common Stock Purchase Warrant dated July 26, 2024 (Filed on July 29, 2024 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

EdgarFiling EXHIBIT 4.2   NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFF

July 29, 2024 EX-4.3

Form of Placement Agent Warrant

EdgarFiling EXHIBIT 4.3   NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFF

July 29, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2024 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

July 29, 2024 EX-4.4

Form of Warrant Inducement Agreement

EdgarFiling EXHIBIT 4.4 Predictive Oncology Inc. July 25, 2024 Holder of Common Stock Purchase Warrants Re: Inducement Offer to Exercise Common Stock Purchase Warrants Dear Holder: Predictive Oncology Inc. (the “Company”) is pleased to offer to you (“Holder”, “you” or similar terminology) (i) the opportunity to receive new warrants to purchase shares of the Company’s common stock, par value $0.000

July 29, 2024 EX-99.1

Predictive Oncology Announces Exercise of Warrants for $1.26 Million Gross Proceeds

EXHIBIT 99.1 Predictive Oncology Announces Exercise of Warrants for $1.26 Million Gross Proceeds PITTSBURGH, July 26, 2024 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI), a leader in AI-driven drug discovery and biologics, today announced that it has entered into a definitive agreement for the exercise of certain existing warrants to purchase an aggregate of 958,117 shares of its commo

May 30, 2024 EX-99.1

Predictive Oncology Announces Positive Results from Ovarian Cancer Study with UPMC Magee-Womens Hospital to be Presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting Study successfully demonstrated Predictive’s ability to b

EXHIBIT 99.1 Predictive Oncology Announces Positive Results from Ovarian Cancer Study with UPMC Magee-Womens Hospital to be Presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting Study successfully demonstrated Predictive’s ability to build AI multi-omic machine learning models to predict survival outcomes among ovarian cancer patients better than clinical data alone PIT

May 30, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 21, 2024 S-3/A

As filed with the Securities and Exchange Commission on May 21, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc.

Registration No. 333-279123 As filed with the Securities and Exchange Commission on May 21, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of inco

May 21, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-3 (Form Type) Predictive Oncology Inc.

May 20, 2024 CORRESP

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201

PREDICTIVE ONCOLOGY INC. 91 43rd Street, Suite 110 Pittsburgh, PA 15201 May 20, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Ms. Jane Park, Staff Attorney Re: Predictive Oncology Inc. Acceleration Request for Registration Statement on Form S-3, as amended File No. 333-279123 Requested Date: May

May 15, 2024 EX-99.1

Predictive Oncology Reports First Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports First Quarter 2024 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 8:30am EDT PITTSBURGH, May 15, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tu

May 15, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictiv

May 13, 2024 LETTER

LETTER

United States securities and exchange commission logo May 13, 2024 Raymond Vennare Chief Executive Officer Predictive Oncology Inc.

May 6, 2024 EX-1.2

Sales Agreement, dated as of May 3, 2024, by and between the Registrant and H.C. Wainwright & Co., LLC.

Exhibit 1.2 Execution Version PREDICTIVE ONCOLOGY INC. Common Stock (par value $0.01 per share) ATM Sales Agreement May 3, 2024 H.C. Wainwright & Co., LLC 430 Park Avenue, 3rd Floor New York, NY 10022 Ladies and Gentlemen: Predictive Oncology Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with H.C. Wainwright & Co., LLC (the “Agent”) as follows: 1. Issuance

May 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 3, 2024 Predictive Oncology I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 3, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or other jurisdiction of incorporation or organization

May 6, 2024 EX-4.43

Form of Indenture

Exhibit 4.43 Predictive Oncology, Inc. INDENTURE Dated as of , 20 [] Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1 Definitions 1 Section 1.2 Other Definitions 4 Section 1.3 Incorporation by Reference of Trust Indenture Act 5 Section 1.4 Rules of Construction 5 ARTICLE II THE SECURITIES 6 Section 2.1 Issuable in Series 6 Section 2.2 Establishment

May 6, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-3 (Form Type) Predictive Oncology Inc.

May 6, 2024 EX-10.1

Sales Agreement, dated as of May 3, 2024, by and between the Registrant and H.C. Wainwright & Co., LLC.

Exhibit 10.1 Execution Version PREDICTIVE ONCOLOGY INC. Common Stock (par value $0.01 per share) ATM Sales Agreement May 3, 2024 H.C. Wainwright & Co., LLC 430 Park Avenue, 3rd Floor New York, NY 10022 Ladies and Gentlemen: Predictive Oncology Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with H.C. Wainwright & Co., LLC (the “Agent”) as follows: 1. Issuanc

May 6, 2024 S-3

As filed with the Securities and Exchange Commission on May 3, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of regis

Registration No. 333- As filed with the Securities and Exchange Commission on May 3, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or jurisdiction (I.R.S. Employer of incorporation or organization)

April 8, 2024 EX-16.1

Letter of BDO USA, P.C. to the Securities and Exchange Commission, dated April 8, 2024.

Exhibit 16.1 Tel: 612-367-3000 Fax: 612-367-3001 www.bdo.com 800 Nicollet Mall, Suite 600 Minneapolis, MN 55402 April 8, 2024 Securities and Exchange Commission 100 F Street N.E. Washington, D.C. 20549 We have been furnished with a copy of the response to Item 4.01 of Form 8-K for the event that occurred on April 3, 2024, to be filed by our former client, Predictive Oncology Inc. We agree with the

April 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2024 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2024 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 28, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 28, 2024 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 28, 2024 EX-99.1

Predictive Oncology Reports Year End 2023 Financial Results and Provides Business Update Company to host investor call and webcast on Monday, April 1st, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports Year End 2023 Financial Results and Provides Business Update Company to host investor call and webcast on Monday, April 1st, at 8:30am EDT PITTSBURGH, March 28, 2024 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of

March 28, 2024 EX-97

Policy Relating to Recovery of Erroneously Awarded Compensation

Exhibit 97 PREDICTIVE ONCOLOGY INC. POLICY ON RECOUPMENT OF INCENTIVE COMPENSATION Purpose The purpose of this policy is to set forth the procedures established by the Predictive Oncology (the “Company”) Board of Directors (the “Board”) for the recoupment of certain executive compensation in the event of an accounting restatement resulting from material noncompliance with the financial reporting r

March 28, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36790 Predictive Oncology Inc.

March 28, 2024 EX-21.1

Subsidiaries of the Registrant

Exhibit 21.1 PREDICTIVE ONCOLOGY INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Corporation Delaware Skyline Medical, Inc. Delaware

March 28, 2024 EX-10.9

Separation Agreement and Mutual Release dated effective September 30, 2023, by and between the Company and Bob Myers.

Exhibit 10.9 SEPARATION AGREEMENT AND MUTUAL RELEASE This Separation Agreement and Mutual Release ("Agreement") is made by and between Robert Myers ("Employee") and Predictive Oncology Inc. (the "Company"), each of whom enter into this Agreement intending to be legally bound. 1. Terms of Employment; Separation Date. a. The terms of Employee's employment with the Company are set forth in that certa

March 22, 2024 8-K/A

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commis

February 8, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 2, 2024 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

January 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 28, 2023 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 28, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

December 7, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

December 5, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

November 14, 2023 EX-99.1

Predictive Oncology Reports Third Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, November 14th, at 8:30am EDT

EXHIBIT 99.1 Predictive Oncology Reports Third Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, November 14th, at 8:30am EDT PITTSBURGH, Nov. 14, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository

November 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 13, 2023 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology

August 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissio

August 10, 2023 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc.

August 10, 2023 EX-99.1

Predictive Oncology Reports Second Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, August 10th, at 5:30pm EDT

EXHIBIT 99.1 Predictive Oncology Reports Second Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, August 10th, at 5:30pm EDT PITTSBURGH, Aug. 10, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): August 10, 2023 Predictive Oncolo

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): August 10, 2023 Predictive Oncology Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 15, 2023 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology Inc

May 15, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission F

May 15, 2023 EX-99.1

Predictive Oncology Reports First Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 5:30pm EDT

EXHIBIT 99.1 Predictive Oncology Reports First Quarter 2023 Financial Results and Provides Business Update Company to host investor call and webcast today, May 15th, at 5:30pm EDT EAGAN, Minn., May 15, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI), a science driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of

May 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2023 Predictive Oncology I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 2, 2023 EX-99.1

Predictive Oncology Appoints Pharma, Biotech and Digital Health Veteran Veena Rao, PhD, MBA, to its Board of Directors

EXHIBIT 99.1 Predictive Oncology Appoints Pharma, Biotech and Digital Health Veteran Veena Rao, PhD, MBA, to its Board of Directors EAGAN, Minn., May 02, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, Clinical Laboratory Improvem

May 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2023 Predictive Oncology I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission Fi

April 20, 2023 EX-99.1

Predictive Oncology Announces Reverse Stock Split Common Stock Will Begin Trading on Split-Adjusted Basis on April 24, 2023

EXHIBIT 99.1 Predictive Oncology Announces Reverse Stock Split Common Stock Will Begin Trading on Split-Adjusted Basis on April 24, 2023 EAGAN, Minn., April 20, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), today announced that it is effecting a reverse stock split of its common stock at a ratio of 1 post-split share for every 20 pre-spli

April 20, 2023 EX-3.1

Certificate of Amendment to Certificate of Incorporation (Filed on April 20, 2023 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.)

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE CERTIFICATE OF INCORPORATION OF PREDICTIVE ONCOLOGY INC. (a Delaware corporation) Pursuant to Section 242 of the Delaware General Corporation Law, the undersigned, being the Chief Financial Officer of Predictive Oncology Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), does hereby certify that the fo

April 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 19, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 19, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

April 18, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

April 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2023 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

April 5, 2023 EX-16.1

Letter of Baker Tilly US, LLP to the Securities and Exchange Commission, dated April 4, 2023 regarding statements included in this Current Report on Form 8-K

Exhibit 16.1 Baker Tilly US, LLP 225 S Sixth St, Ste 2300 Minneapolis, MN 55402-4661 T: +1 (612) 876 4500 F: +1 (612) 238 8900 bakertilly.com April 4, 2023 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Ladies and Gentlemen: We have read Item 4.01 of Form 8-K, dated on or about April 4, 2023, of Predictive Oncology Inc. and agree with the statements contained in the sec

March 29, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

March 21, 2023 EX-21.1

Subsidiaries of the Registrant

Exhibit 21.1 PREDICTIVE ONCOLOGY INC. SUBSIDIARIES OF THE REGISTRANT Subsidiary Jurisdiction of Incorporation Helomics Corporation Delaware Skyline Medical, Inc. Delaware

March 21, 2023 EX-99.1

Predictive Oncology Reports Year End 2022 Financial Results and Provides Business Update

EXHIBIT 99.1 Predictive Oncology Reports Year End 2022 Financial Results and Provides Business Update EAGAN, Minn., March 21, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (Nasdaq: POAI), a science-driven company leveraging its proprietary artificial intelligence and machine learning capabilities, extensive biorepository of tumor samples, Clinical Laboratory Improvement Amendments (CLIA) labora

March 21, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2022.

March 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 17, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

March 16, 2023 8-A12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 Predictive Oncology Inc. (Exact name of regis

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 33-1007393 (State or other jurisdiction of incorporation or organization) (IRS Employer Identification No.

March 16, 2023 EX-99.1

Predictive Oncology Announces Distribution of Series F Preferred Stock to Holders of its Common Stock

EXHIBIT 99.1 Predictive Oncology Announces Distribution of Series F Preferred Stock to Holders of its Common Stock EAGAN, Minn., March 16, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) (“Predictive Oncology” or the “Company”), today announced that its Board of Directors declared a dividend of one one-thousandth of a share of newly designated Series F Preferred Stock, par value $0

March 16, 2023 EX-3.1

Certificate of Designation of Series F Preferred Stock (Filed on March 16, 2023 as an exhibit to the Form 8-A and incorporated herein by reference.)

Exhibit 3.1 PREDICTIVE ONCOLOGY INC. CERTIFICATE OF DESIGNATION OF SERIES F PREFERRED STOCK Pursuant to Section 151 of the General Corporation Law of the State of Delaware Pursuant to Section 151 of the General Corporation Law of the State of Delaware, Predictive Oncology Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware, in accordance with the p

March 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 14, 2023 EX-99.1

Predictive Oncology Engages LifeSci Advisors as Strategic Investor Relations Partner Comprehensive, multi-faceted IR program to focus on raising awareness of Predictive Oncology and its portfolio of unique, proprietary assets capable of accelerating

EXHIBIT 99.1 Predictive Oncology Engages LifeSci Advisors as Strategic Investor Relations Partner Comprehensive, multi-faceted IR program to focus on raising awareness of Predictive Oncology and its portfolio of unique, proprietary assets capable of accelerating oncologic drug discovery and enabling drug development EAGAN, Minn., March 14, 2023 (GLOBE NEWSWIRE) - Predictive Oncology (Nasdaq: POAI)

March 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2023 Predictive Oncolog

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

March 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2023 Predictive Oncology

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission

February 28, 2023 EX-10.1

Employment Agreement dated February 23, 2023 by and between Pamela Bush and Predictive Oncology Inc.

Exhibit 10.1 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (“Agreement”) made and entered into on February 23, 2023, to be effective as of February 1, 2023 (the “Effective Date”) by and between Pamela Bush, an individual, residing at 13418 Canopy Creek Drive, Tampa, Florida 33625 (“Employee”), and Predictive Oncology Inc., 2915 Commers Drive, Suite 900, E

February 28, 2023 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2023 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Inco

February 3, 2023 EX-99.1

Predictive Oncology Appoints Pamela Bush, Ph.D., MBA, as Chief Business Officer

Exhibit 99.1 Predictive Oncology Appoints Pamela Bush, Ph.D., MBA, as Chief Business Officer EAGAN, Minn., Feb. 03, 2023 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) is pleased to announce the appointment of Pamela Bush, Ph.D., MBA, as Chief Business Officer. Dr. Bush will lead all business development, partnering and growth strategies for Predictive Oncology. As a key member of the

February 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2023 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 30, 2023 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

December 5, 2022 EX-99.1

Predictive Oncology Appoints Leading Biopharma Executive Matthew J. Hawryluk Ph.D. to the Board of Directors

EXHIBIT 99.1 Predictive Oncology Appoints Leading Biopharma Executive Matthew J. Hawryluk Ph.D. to the Board of Directors EAGAN, Minn., Dec. 05, 2022 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) is pleased to announce the appointment of Matthew J. Hawryluk, Ph.D., (www.predictive-oncology.com) to its Board of Directors to help support the company?s strategic initiatives and commercia

December 5, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 29, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

December 2, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

November 10, 2022 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36790 Predictive Oncology

November 10, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Predictive Onco

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commiss

November 10, 2022 EX-99.1

Predictive Oncology Reports Third Quarter Financial Results

Exhibit 99.1 Predictive Oncology Reports Third Quarter Financial Results EAGAN, Minn., Nov. 10, 2022 (GLOBE NEWSWIRE) - Predictive Oncology Inc. (NASDAQ: POAI) today announced the financial results for its third quarter ended September 30, 2022, which continue to reflect revenue growth and increased gross profit margin as compared to prior year periods. Highlights from the quarter include: Raymond

October 25, 2022 EX-99.1

David S. Smith appointed to the Board of Directors of Predictive Oncology Leading authority on the therapeutic use of human tissues and cells

Exhibit 99.1 David S. Smith appointed to the Board of Directors of Predictive Oncology Leading authority on the therapeutic use of human tissues and cells EAGAN, Minn., Oct. 25, 2022 (GLOBE NEWSWIRE) – Predictive Oncology (NASDAQ: POAI) is pleased to announce the appointment of David S. Smith, JD, to the company’s Board of Directors. Mr. Smith is a life sciences and corporate attorney, veteran bio

October 25, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 19, 2022 Predictive Oncol

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 19, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commissi

October 20, 2022 EX-10.1

Employment Offer Letter dated September 30, 2022, by and between the Company and Raymond F. Vennare. (Filed on September 22, 2022 as an exhibit to our Current Report on Form 8-K).

EX-10.1 2 exh101.htm EXHIBIT 10.1 Exhibit 10.1 September 30, 2022 Raymond Vennare 179 West Hutchinson Avenue Pittsburgh, PA 1528-1321 Dear Raymond: On behalf of Predictive Oncology Inc. (the “Company”), I am very pleased to offer you the position of Chief Executive Officer of Predictive Oncology Inc. This letter establishes the terms of your employment with the Company if you accept this offer. Yo

October 20, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: September 22, 2022 Predictive Oncology Inc. (Exact name of Registra

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: September 22, 2022 Predictive Oncology Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commission File Number) (IRS Employer Id

October 20, 2022 EX-10.2

Employment Agreement dated effective November 1, 2022, by and between the Company and Raymond F. Vennare. (Filed on October 20, 2022 as an exhibit to our Current Report on Form 8-K).

Exhibit 10.2 EMPLOYMENT AGREEMENT This Employment Agreement (?Agreement?) made and entered into effective as of the 1st day of November 2022 (the ?Effective Date?) by and between Raymond F. Vennare, an individual, residing at 179 West Hutchinson Avenue, Pittsburgh, PA 15218, and Predictive Oncology Inc., 2915 Commers Drive, Suite 900, Eagan, Minnesota 55121, a Delaware corporation (?Company?), col

October 20, 2022 EX-99.1

Predictive Oncology Announces New Chief Executive Officer Raymond F. Vennare to Lead Company Growth

EXHIBIT 99.1 Predictive Oncology Announces New Chief Executive Officer Raymond F. Vennare to Lead Company Growth EAGAN, Minn., Oct. 20, 2022 (GLOBE NEWSWIRE) - Predictive Oncology (NASDAQ: POAI) is pleased to announce the appointment of Raymond F. Vennare as Chief Executive Officer and Chairman of the Board, effective Nov. 1. As an active member on the POAI Board of Directors since September 2021

October 18, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

October 18, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

October 13, 2022 424B3

PREDICTIVE ONCOLOGY INC. 4,737,280 Shares Common Stock

Filed pursuant to 424(b)(3) Registration No. 333-267689 PROSPECTUS PREDICTIVE ONCOLOGY INC. 4,737,280 Shares Common Stock This prospectus relates to the offer and resale from time to time by the selling stockholders named in this prospectus of up to an aggregate of 4,737,280 shares of our common stock, par value $0.01 per share. These shares consist of (i) 3,837,280 shares of common stock issuable

October 11, 2022 CORRESP

Predictive Oncology, Inc. 2915 Commers Drive, Suite 900 Eagan, MN 55121

CORRESP 1 filename1.htm Predictive Oncology, Inc. 2915 Commers Drive, Suite 900 Eagan, MN 55121 October 11, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Benjamin Richie Re: Predictive Oncology, Inc. Registration Statement on Form S-1 File No. 333-267689 Ladies and Gentlemen: Pursuant to Rule 461 u

October 6, 2022 LETTER

LETTER

United States securities and exchange commission logo October 6, 2022 Bob Myers Chief Financial Officer Predictive Oncology Inc.

September 30, 2022 EX-3.10

Second Amended and Restated Bylaws of the Company, effective as of September 9, 2022 (Filed on September 30, 2022 as an exhibit to our Registration Statement on Form S-1 (File No. 333-267689).

Exhibit 3.10 SECOND Amended and Restated BYLAWS of PREDICTIVE ONCOLOGY INC. Effective as of September 9, 2022 ARTICLE 1. OFFICES Section 1.01. Registered Office. The registered office of the Corporation shall be in the City of Wilmington, County of New Castle, State of Delaware. Section 1.02. Other Offices. The Corporation may also have offices at such other places both within and without the Stat

September 30, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables S-1 (Form Type) Predictive Oncology Inc.

September 30, 2022 S-1

As filed with the Securities and Exchange Commission on September 30, 2022 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name o

S-1 1 fs1093022.htm FORM S-1 Registration No. 333- As filed with the Securities and Exchange Commission on September 30, 2022 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 3842 33-1007393 (State or jurisdiction (Primary

September 16, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 15, 2022 Predictive Oncology Inc. (Exact name of registrant as specified in its charter) Delaware 001-36790 33-1007393 (State or Other Jurisdiction of Incorporation) (Commis

September 16, 2022 EX-10.1

Exhibit 10.2

Exhibit 10.1 TRANSITION AND SEPARATION AGREEMENT This Transition and Separation Agreement (?Agreement?) is made and entered into effective as of September 15, 2022, by and between J. Melville Engle (?Employee?) and Predictive Oncology Inc., a Delaware corporation (?the Company?), each of whom enter into this Agreement intending to be legally bound. RECITALS The Company and Employee agree upon the

September 16, 2022 EX-99.1

Predictive Oncology Announces CEO Retirement

EXHIBIT 99.1 Predictive Oncology Announces CEO Retirement EAGAN, Minn., Sept. 16, 2022 (GLOBE NEWSWIRE) - Predictive Oncology (NASDAQ: POAI) today announced that J. Melville (?Mel?) Engle will retire as Chief Executive Officer and as Chairman and a member of the company?s Board of Directors. To ensure a smooth transition of his responsibilities, Mr. Engle will continue to serve in his role through

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